Multiple serologic reactions and their relationship to clinical activity in systemic lupus erythematosus

David A. Isenberg, Yehuda Shoenfeld, Robert S. Schwartz

Research output: Contribution to journalArticlepeer-review

Abstract

Analysis of the binding of serum from 56 systemic lupus erythematosus patients to native DNA (nDNA), denatured DNA (dDNA), poly I, poly(dT), RNA, and cardiolipin revealed multiple antigen binding in many of the sera. Raised levels of antibodies (IgG and/or IgM) to denatured DNA were found in the highest percentage (68%) of patients. A small subset of patients with multiple raised IgM antibodies, renal disease, and vasculitic skin rash was identified. No correlation between multiple serologic activity and clinical disease was found.

Original languageEnglish
Pages (from-to)132-138
Number of pages7
JournalArthritis and Rheumatology
Volume27
Issue number2
DOIs
StatePublished - Feb 1984
Externally publishedYes

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