TY - JOUR
T1 - Multiple serologic reactions and their relationship to clinical activity in systemic lupus erythematosus
AU - Isenberg, David A.
AU - Shoenfeld, Yehuda
AU - Schwartz, Robert S.
PY - 1984/2
Y1 - 1984/2
N2 - Analysis of the binding of serum from 56 systemic lupus erythematosus patients to native DNA (nDNA), denatured DNA (dDNA), poly I, poly(dT), RNA, and cardiolipin revealed multiple antigen binding in many of the sera. Raised levels of antibodies (IgG and/or IgM) to denatured DNA were found in the highest percentage (68%) of patients. A small subset of patients with multiple raised IgM antibodies, renal disease, and vasculitic skin rash was identified. No correlation between multiple serologic activity and clinical disease was found.
AB - Analysis of the binding of serum from 56 systemic lupus erythematosus patients to native DNA (nDNA), denatured DNA (dDNA), poly I, poly(dT), RNA, and cardiolipin revealed multiple antigen binding in many of the sera. Raised levels of antibodies (IgG and/or IgM) to denatured DNA were found in the highest percentage (68%) of patients. A small subset of patients with multiple raised IgM antibodies, renal disease, and vasculitic skin rash was identified. No correlation between multiple serologic activity and clinical disease was found.
UR - http://www.scopus.com/inward/record.url?scp=0021368742&partnerID=8YFLogxK
U2 - 10.1002/art.1780270203
DO - 10.1002/art.1780270203
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AN - SCOPUS:0021368742
VL - 27
SP - 132
EP - 138
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
SN - 2326-5191
IS - 2
ER -