Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft

Anat Bar-Shira; Jehonathan H. Pinthus; Uri Rozovsky; Myriam Goldstein; William R. Sellers; Yuval Yaron; Zelig Eshhar; Avi Orr-Urtreger

Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft

Anat Bar-Shira, Jehonathan H. Pinthus, Uri Rozovsky, Myriam Goldstein, William R. Sellers, Yuval Yaron, Zelig Eshhar, Avi Orr-Urtreger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

We analyzed a prostate cancer xenograft derived from a locally advanced tumor using combined cytogenetic, array-based comparative genomic hybridization and expression analyses. This analysis revealed that genes in the 20q13 chromosomal region, CSE1L, ZNF217, MYBL2, and STK15, were significantly overexpressed in this tumor. The expression pattern of these genes was then confirmed in two large human prostate cancer microarray databases. Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases. Our data suggest these genes to be involved in advanced stages of prostate tumorigenesis and as such, they may serve as markers for tumor progression.

Original language	English
Pages (from-to)	6803-6807
Number of pages	5
Journal	Cancer Research
Volume	62
Issue number	23
State	Published - 1 Dec 2002

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title = "Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft",

abstract = "We analyzed a prostate cancer xenograft derived from a locally advanced tumor using combined cytogenetic, array-based comparative genomic hybridization and expression analyses. This analysis revealed that genes in the 20q13 chromosomal region, CSE1L, ZNF217, MYBL2, and STK15, were significantly overexpressed in this tumor. The expression pattern of these genes was then confirmed in two large human prostate cancer microarray databases. Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases. Our data suggest these genes to be involved in advanced stages of prostate tumorigenesis and as such, they may serve as markers for tumor progression.",

author = "Anat Bar-Shira and Pinthus, {Jehonathan H.} and Uri Rozovsky and Myriam Goldstein and Sellers, {William R.} and Yuval Yaron and Zelig Eshhar and Avi Orr-Urtreger",

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T1 - Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft

AU - Bar-Shira, Anat

AU - Pinthus, Jehonathan H.

AU - Rozovsky, Uri

AU - Goldstein, Myriam

AU - Sellers, William R.

AU - Yaron, Yuval

AU - Eshhar, Zelig

AU - Orr-Urtreger, Avi

PY - 2002/12/1

Y1 - 2002/12/1

N2 - We analyzed a prostate cancer xenograft derived from a locally advanced tumor using combined cytogenetic, array-based comparative genomic hybridization and expression analyses. This analysis revealed that genes in the 20q13 chromosomal region, CSE1L, ZNF217, MYBL2, and STK15, were significantly overexpressed in this tumor. The expression pattern of these genes was then confirmed in two large human prostate cancer microarray databases. Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases. Our data suggest these genes to be involved in advanced stages of prostate tumorigenesis and as such, they may serve as markers for tumor progression.

AB - We analyzed a prostate cancer xenograft derived from a locally advanced tumor using combined cytogenetic, array-based comparative genomic hybridization and expression analyses. This analysis revealed that genes in the 20q13 chromosomal region, CSE1L, ZNF217, MYBL2, and STK15, were significantly overexpressed in this tumor. The expression pattern of these genes was then confirmed in two large human prostate cancer microarray databases. Furthermore, the MYBL2 and STK15 have been significantly overexpressed in prostate metastases, allowing a clear distinction between localized tumors and metastases. Our data suggest these genes to be involved in advanced stages of prostate tumorigenesis and as such, they may serve as markers for tumor progression.

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JO - Cancer Research

JF - Cancer Research

IS - 23

ER -

Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft

Abstract

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