TY - JOUR
T1 - Multiple conformational selection and induced fit events take place in allosteric propagation
AU - Nussinov, Ruth
AU - Ma, Buyong
AU - Tsai, Chung Jung
N1 - Funding Information:
This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health , under contract number HHSN261200800001E . The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported (in part) by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research .
PY - 2014/2
Y1 - 2014/2
N2 - The fact that we observe a single conformational selection event during binding does not necessarily mean that only a single conformational selection event takes place, even though this is the common assumption. Here we suggest that conformational selection takes place not once in a given binding/allosteric event, but at every step along the allosteric pathway. This view generalizes conformational selection and makes it applicable also to other allosteric events, such as post-translational modifications (PTMs) and photon absorption. Similar to binding, at each step along a propagation pathway, conformational selection is coupled with induced fit which optimizes the interactions. Thus, as in binding, the allosteric effects induced by PTMs and light relate not only to population shift; but to conformational selection as well. Conformational selection and population shift take place conjointly.
AB - The fact that we observe a single conformational selection event during binding does not necessarily mean that only a single conformational selection event takes place, even though this is the common assumption. Here we suggest that conformational selection takes place not once in a given binding/allosteric event, but at every step along the allosteric pathway. This view generalizes conformational selection and makes it applicable also to other allosteric events, such as post-translational modifications (PTMs) and photon absorption. Similar to binding, at each step along a propagation pathway, conformational selection is coupled with induced fit which optimizes the interactions. Thus, as in binding, the allosteric effects induced by PTMs and light relate not only to population shift; but to conformational selection as well. Conformational selection and population shift take place conjointly.
KW - Allosteric
KW - Allostery
KW - Binding
KW - Conformational selection
KW - Induced fit
KW - Molecular recognition
UR - http://www.scopus.com/inward/record.url?scp=84894246676&partnerID=8YFLogxK
U2 - 10.1016/j.bpc.2013.10.002
DO - 10.1016/j.bpc.2013.10.002
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AN - SCOPUS:84894246676
SN - 0301-4622
VL - 186
SP - 22
EP - 30
JO - Biophysical Chemistry
JF - Biophysical Chemistry
ER -