Multinuclear NMR and MRI studies of the maturation of pig articular cartilage

Keren Keinan-Adamsky, Hadassah Shinar, Gil Navon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The maturation of pig articular cartilage was followed by 2H in-phase double quantum filtered (IP-DQF) spectroscopic MRI, 1H T2 MRI, and 23Na DQF and triple quantum filtered MRS. The results all lead to the conclusion that the order and density of the collagen fibers in articular cartilage increase from birth to maturity. At birth, both 2H IP-DQF signal and 1H T2 were homogeneous throughout the cartilage and their values independent of the orientation of the plug relative to the magnetic field. At maturation, the 2H IP-DQF spectrum near the bone is composed of two pairs of quadrupolar split satellites and the 1H T2 relaxation is biexponential, indicating the presence of two groups of collagen fibers. The 2H satellites are orientation dependent, indicating that the two groups of fibers are well ordered at maturation. The fast component of 1H T2 is also orientation dependent and thus we have concluded that this component results from residual dipolar interaction, while the slow T2 component in mature cartilage, as well as the T2 relaxation in immature cartilage, is governed by other mechanisms.

Original languageEnglish
Pages (from-to)532-540
Number of pages9
JournalMagnetic Resonance in Medicine
Volume55
Issue number3
DOIs
StatePublished - Mar 2006

Keywords

  • Articular cartilage
  • H DQF spectroscopic MRI
  • H T
  • Maturation of cartilage
  • Na DQF and TQF

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