TY - JOUR
T1 - Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis
AU - Gracien, René Maxime
AU - Jurcoane, Alina
AU - Wagner, Marlies
AU - Reitz, Sarah C.
AU - Mayer, Christoph
AU - Volz, Steffen
AU - Hof, Stephanie Michelle
AU - Fleischer, Vinzenz
AU - Droby, Amgad
AU - Steinmetz, Helmuth
AU - Groppa, Sergiu
AU - Hattingen, Elke
AU - Deichmann, Ralf
AU - Klein, Johannes C.
N1 - Publisher Copyright:
© 2016 International Society for Magnetic Resonance in Medicine
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Purpose: To investigate magnetization transfer ratio (MTR), T1 relaxation time, and proton density (PD) as indicators of gray matter damage in relapsing-remitting multiple sclerosis (RRMS), reflecting different aspects of microstructural damage and as imaging correlates of clinical disability. We aimed to determine which of these parameters may optimally quantify cortical damage, and serve as an imaging surrogate of clinical disability. In this study, cortical values of MTR, a surrogate for demyelination in MS, of PD, reflecting replacement of neural tissue by water, and of T1, indicating a complex array of microstructural changes, were assessed in a group of RRMS patients in comparison to healthy controls (HC). Materials and Methods: 22 RRMS patients with varying disease duration (4.0 ± 6.54 years) and 10 HC received quantitative 3T magnetic resonance imaging (MRI) with MTR, T1, and PD mapping. We tested for differences in cortical measurements between patients and HC. Additionally, correlation with disability as quantified by the Expanded Disability Status Scale was investigated. Results: Cortical parameter values were significantly altered in the RRMS group, with increased values of T1 (P = 0.008) and PD (P = 0.028) and reduced values of MTR (P = 0.043). Only cortical T1 was correlated with clinical disability measurements (P = 0.001, r = 0.65). Receiver operating characteristic analysis demonstrated the best discriminatory power for T1 (area under the curve 0.79, PD: 0.75, MTR 0.73). Conclusion: Out of the parameters studied, cortical T1 is best suited to detect cortical damage as an imaging surrogate of clinical disability in RRMS. J. Magn. Reson. Imaging 2016;44:1600–1607.
AB - Purpose: To investigate magnetization transfer ratio (MTR), T1 relaxation time, and proton density (PD) as indicators of gray matter damage in relapsing-remitting multiple sclerosis (RRMS), reflecting different aspects of microstructural damage and as imaging correlates of clinical disability. We aimed to determine which of these parameters may optimally quantify cortical damage, and serve as an imaging surrogate of clinical disability. In this study, cortical values of MTR, a surrogate for demyelination in MS, of PD, reflecting replacement of neural tissue by water, and of T1, indicating a complex array of microstructural changes, were assessed in a group of RRMS patients in comparison to healthy controls (HC). Materials and Methods: 22 RRMS patients with varying disease duration (4.0 ± 6.54 years) and 10 HC received quantitative 3T magnetic resonance imaging (MRI) with MTR, T1, and PD mapping. We tested for differences in cortical measurements between patients and HC. Additionally, correlation with disability as quantified by the Expanded Disability Status Scale was investigated. Results: Cortical parameter values were significantly altered in the RRMS group, with increased values of T1 (P = 0.008) and PD (P = 0.028) and reduced values of MTR (P = 0.043). Only cortical T1 was correlated with clinical disability measurements (P = 0.001, r = 0.65). Receiver operating characteristic analysis demonstrated the best discriminatory power for T1 (area under the curve 0.79, PD: 0.75, MTR 0.73). Conclusion: Out of the parameters studied, cortical T1 is best suited to detect cortical damage as an imaging surrogate of clinical disability in RRMS. J. Magn. Reson. Imaging 2016;44:1600–1607.
KW - MTR
KW - T relaxation time
KW - cortical gray matter
KW - multiple sclerosis
KW - proton density
KW - quantitative MRI
UR - http://www.scopus.com/inward/record.url?scp=84994813305&partnerID=8YFLogxK
U2 - 10.1002/jmri.25297
DO - 10.1002/jmri.25297
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C2 - 27153293
AN - SCOPUS:84994813305
SN - 1053-1807
VL - 44
SP - 1600
EP - 1607
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 6
ER -