Multifunctional Nanovaccine Sensitizes Breast Cancer to Immune Checkpoint Therapy

Carina Peres, Ana I. Matos, Bárbara Carreira, Liane I.F. Moura, Ron Kleiner, Daniella Vaskovich-Koubi, Keren Reshef, Shai Dulberg, Mafalda Verdial, João Conniot, Marta B. Afonso, Rita C. Acúrcio, Afonso P. Basto, Sofia Mensurado, Bruno Silva-Santos, Susana Constantino Rosa Santos, Ana S. Viana, Liana C. Silva, Cecília M.P. Rodrigues, Véronique PréatLuís Graça, Asaf Madi, Ronit Satchi-Fainaro*, Helena F. Florindo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Breast cancer is the primary cause of cancer-related death in women worldwide. Breast cancer subtypes are characterized by different gene expression patterns, which drive their prognostic factors and therapeutic options. Among them, triple-negative breast cancer (TNBC) is one of the deadliest due to its aggressiveness, high rate of early recurrence and distant metastases, and limited therapeutic options. Despite the recent approval of monoclonal antibodies targeting programmed cell death protein 1 (PD-1) or its ligand (PD-L1) for the treatment of TNBC patients with a locally recurrent unresectable or metastatic tumor expressing PD-L1, their response rate is very modest. It is reported that polymeric nanoparticle (NP)-based cancer vaccines, co-entrapping tumor-associated antigens, Toll-like receptor ligands and small interfering RNA (siRNA) targeting the expression of the immunosuppressive cytokine transforming growth factor (TGF)-β1 by dendritic cells, sensitized TNBC to the agonist immune checkpoint OX40, inhibiting tumor growth and increasing overall survival. This anti-tumor immune-mediated effect is also observed in a luminal type of mammary cancer similar to human disease. Therefore, these synergistic anticancer effects of αOX40 and the antigen-specific adaptive immunity induced by nanovaccine-mediated TGF-β silencing may guide the development of novel combination regimens able to improve the response rate to this aggressive tumor.

Original languageEnglish
Article number2401749
JournalAdvanced Functional Materials
Volume34
Issue number33
DOIs
StatePublished - 14 Aug 2024

Keywords

  • OX40 and PD-1
  • RNA and vaccine co-delivery
  • luminal B mammary cancer
  • nanotechnology
  • triple-negative breast cancer

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