Multifunctional microelectronic fibers enable wireless modulation of gut and brain neural circuits

Atharva Sahasrabudhe, Laura E. Rupprecht, Sirma Orguc, Tural Khudiyev, Tomo Tanaka, Joanna Sands, Weikun Zhu, Anthony Tabet, Marie Manthey, Harrison Allen, Gabriel Loke, Marc Joseph Antonini, Dekel Rosenfeld, Jimin Park, Indie C. Garwood, Wei Yan, Farnaz Niroui, Yoel Fink, Anantha Chandrakasan, Diego V. BohórquezPolina Anikeeva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Progress in understanding brain–viscera interoceptive signaling is hindered by a dearth of implantable devices suitable for probing both brain and peripheral organ neurophysiology during behavior. Here we describe multifunctional neural interfaces that combine the scalability and mechanical versatility of thermally drawn polymer-based fibers with the sophistication of microelectronic chips for organs as diverse as the brain and the gut. Our approach uses meters-long continuous fibers that can integrate light sources, electrodes, thermal sensors and microfluidic channels in a miniature footprint. Paired with custom-fabricated control modules, the fibers wirelessly deliver light for optogenetics and transfer data for physiological recording. We validate this technology by modulating the mesolimbic reward pathway in the mouse brain. We then apply the fibers in the anatomically challenging intestinal lumen and demonstrate wireless control of sensory epithelial cells that guide feeding behaviors. Finally, we show that optogenetic stimulation of vagal afferents from the intestinal lumen is sufficient to evoke a reward phenotype in untethered mice.

Original languageEnglish
Pages (from-to)892-904
Number of pages13
JournalNature Biotechnology
Volume42
Issue number6
DOIs
StatePublished - Jun 2024
Externally publishedYes

Funding

FundersFunder number
Center for Materials Science and EngineeringDMR-1419807
Institute for Soldier NanotechnologiesW911NF-13-D-000
National Science Foundation
National Institutes of Health
U.S. Department of DefenseSA21-03
U.S. Department of Defense
National Institute of Mental HealthDP2-MH122402
National Institute of Mental Health
National Institute of Diabetes and Digestive and Kidney DiseasesR01-DK131112, F32-DK127727
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Neurological Disorders and StrokeR01-NS115025-01A1
National Institute of Neurological Disorders and Stroke
Army Research Office
Defense Threat Reduction Agency
Army Research Laboratory
Massachusetts Institute of TechnologyNA18OAR4170105
Massachusetts Institute of Technology
National Center for Complementary and Integrative HealthDP1-AT011991
National Center for Complementary and Integrative Health
McGovern Institute for Brain Research, Massachusetts Institute of Technology
Center for Neurotechnology, University of WashingtonEEC-1028725, R21-AT010818
Center for Neurotechnology, University of Washington
Kwanjeong Educational Foundation

    Fingerprint

    Dive into the research topics of 'Multifunctional microelectronic fibers enable wireless modulation of gut and brain neural circuits'. Together they form a unique fingerprint.

    Cite this