TY - JOUR
T1 - Multifunctional microelectronic fibers enable wireless modulation of gut and brain neural circuits
AU - Sahasrabudhe, Atharva
AU - Rupprecht, Laura E.
AU - Orguc, Sirma
AU - Khudiyev, Tural
AU - Tanaka, Tomo
AU - Sands, Joanna
AU - Zhu, Weikun
AU - Tabet, Anthony
AU - Manthey, Marie
AU - Allen, Harrison
AU - Loke, Gabriel
AU - Antonini, Marc Joseph
AU - Rosenfeld, Dekel
AU - Park, Jimin
AU - Garwood, Indie C.
AU - Yan, Wei
AU - Niroui, Farnaz
AU - Fink, Yoel
AU - Chandrakasan, Anantha
AU - Bohórquez, Diego V.
AU - Anikeeva, Polina
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2024/6
Y1 - 2024/6
N2 - Progress in understanding brain–viscera interoceptive signaling is hindered by a dearth of implantable devices suitable for probing both brain and peripheral organ neurophysiology during behavior. Here we describe multifunctional neural interfaces that combine the scalability and mechanical versatility of thermally drawn polymer-based fibers with the sophistication of microelectronic chips for organs as diverse as the brain and the gut. Our approach uses meters-long continuous fibers that can integrate light sources, electrodes, thermal sensors and microfluidic channels in a miniature footprint. Paired with custom-fabricated control modules, the fibers wirelessly deliver light for optogenetics and transfer data for physiological recording. We validate this technology by modulating the mesolimbic reward pathway in the mouse brain. We then apply the fibers in the anatomically challenging intestinal lumen and demonstrate wireless control of sensory epithelial cells that guide feeding behaviors. Finally, we show that optogenetic stimulation of vagal afferents from the intestinal lumen is sufficient to evoke a reward phenotype in untethered mice.
AB - Progress in understanding brain–viscera interoceptive signaling is hindered by a dearth of implantable devices suitable for probing both brain and peripheral organ neurophysiology during behavior. Here we describe multifunctional neural interfaces that combine the scalability and mechanical versatility of thermally drawn polymer-based fibers with the sophistication of microelectronic chips for organs as diverse as the brain and the gut. Our approach uses meters-long continuous fibers that can integrate light sources, electrodes, thermal sensors and microfluidic channels in a miniature footprint. Paired with custom-fabricated control modules, the fibers wirelessly deliver light for optogenetics and transfer data for physiological recording. We validate this technology by modulating the mesolimbic reward pathway in the mouse brain. We then apply the fibers in the anatomically challenging intestinal lumen and demonstrate wireless control of sensory epithelial cells that guide feeding behaviors. Finally, we show that optogenetic stimulation of vagal afferents from the intestinal lumen is sufficient to evoke a reward phenotype in untethered mice.
UR - http://www.scopus.com/inward/record.url?scp=85162948714&partnerID=8YFLogxK
U2 - 10.1038/s41587-023-01833-5
DO - 10.1038/s41587-023-01833-5
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C2 - 37349522
AN - SCOPUS:85162948714
SN - 1087-0156
VL - 42
SP - 892
EP - 904
JO - Nature Biotechnology
JF - Nature Biotechnology
IS - 6
ER -