MultiFit: A web server for fitting multiple protein structures into their electron microscopy density map

Elina Tjioe, Keren Lasker, Ben Webb, Haim J. Wolfson, Andrej Sali

Research output: Contribution to journalArticlepeer-review

Abstract

Advances in electron microscopy (EM) allow for structure determination of large biological assemblies at increasingly higher resolutions. A key step in this process is fitting multiple component structures into an EM-derived density map of their assembly. Here, we describe a web server for this task. The server takes as input a set of protein structures in the PDB format and an EM density map in the MRC format. The output is an ensemble of models ranked by their quality of fit to the density map. The models can be viewed online or downloaded from the website. The service is available at; http://salilab.org/multifit/ and http://bioinfo3d.cs.tau.ac.il/.

Original languageEnglish
Pages (from-to)W167-W170
JournalNucleic Acids Research
Volume39
Issue numberSUPPL. 2
DOIs
StatePublished - 1 Jul 2011

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