TY - JOUR
T1 - Multifetal reduction of triplets to twins compared with non-reduced twins
T2 - a meta-analysis
AU - Zipori, Yaniv
AU - Haas, Jigal
AU - Berger, Howard
AU - Barzilay, Eran
N1 - Publisher Copyright:
© 2017 Reproductive Healthcare Ltd.
PY - 2017/7
Y1 - 2017/7
N2 - The current systematic review and meta-analysis evaluates the perinatal outcomes in twin pregnancies following multifetal pregnancy reduction (MPR) compared with non-reduced twins. We considered all studies comparing perinatal outcomes of twin pregnancies following MPR to non-reduced twin pregnancies. Our search yielded 639 publications, of which 91 were assessed for eligibility. A total of 22 studies met our inclusion criteria. Overall, fetal reduction of triplets to twins resulted in comparable perinatal outcomes to non-reduced twins with regards to gestational age and birthweight at delivery, pregnancy loss prior to 24 weeks, as well as the development of gestational diabetes and hypertensive disorders of pregnancy. Of all outcomes, only the Caesarean section rate was significantly higher in the MPR group compared with the non-reduced twins group with an odds ratio of 1.95 (95% confidence interval 1.33–2.87). This meta-analysis suggests that MPR of triplet pregnancies to twins is associated with comparable perinatal outcomes to that of non-reduced twins. This information can further help in guiding, and probably reassuring, clinician and patient decision-making when faced with high-order multifetal pregnancies.
AB - The current systematic review and meta-analysis evaluates the perinatal outcomes in twin pregnancies following multifetal pregnancy reduction (MPR) compared with non-reduced twins. We considered all studies comparing perinatal outcomes of twin pregnancies following MPR to non-reduced twin pregnancies. Our search yielded 639 publications, of which 91 were assessed for eligibility. A total of 22 studies met our inclusion criteria. Overall, fetal reduction of triplets to twins resulted in comparable perinatal outcomes to non-reduced twins with regards to gestational age and birthweight at delivery, pregnancy loss prior to 24 weeks, as well as the development of gestational diabetes and hypertensive disorders of pregnancy. Of all outcomes, only the Caesarean section rate was significantly higher in the MPR group compared with the non-reduced twins group with an odds ratio of 1.95 (95% confidence interval 1.33–2.87). This meta-analysis suggests that MPR of triplet pregnancies to twins is associated with comparable perinatal outcomes to that of non-reduced twins. This information can further help in guiding, and probably reassuring, clinician and patient decision-making when faced with high-order multifetal pregnancies.
KW - Meta-analysis
KW - Multifetal pregnancy reduction
KW - Non-reduced twins
KW - Perinatal outcome
KW - Triplets
UR - http://www.scopus.com/inward/record.url?scp=85018622536&partnerID=8YFLogxK
U2 - 10.1016/j.rbmo.2017.04.001
DO - 10.1016/j.rbmo.2017.04.001
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C2 - 28434652
AN - SCOPUS:85018622536
SN - 1472-6483
VL - 35
SP - 87
EP - 93
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
IS - 1
ER -