@article{7c4c644c9ecf4121bb774ab30f400c6a,
title = "Multifaceted action of Fuzeon as virus-cell membrane fusion inhibitor",
abstract = "The viral peptide fusion inhibitor Fuzeon (T-20/DP178/enfuvirtide) is an essential part of the drug combination that has significantly increased the quality of life and life span of many acquired immuno-deficiency syndrome (AIDS) patients. Its development as a drug preceded the elucidation of its precise inhibitory mechanism, as well as its molecular targets. The initial model was that Fuzeon inhibits human immunodeficiency virus (HIV) entry by targeting one site within the viral transmembrane envelope protein. Herein, we describe the emerging discoveries that extend this model towards a multifaceted mechanism for the drug in targeting HIV. This significantly advances the understanding of how viruses enter host cells and opens a new window of opportunity for designing future viral fusion inhibitors.",
keywords = "HIV entry inhibitor, Membrane fusion, Transmembrane protein, Viral envelope protein",
author = "Avraham Ashkenazi and Yael Wexler-Cohen and Yechiel Shai",
note = "Funding Information: We thank Winfried Weissenhorn for supplying the recent 3D structure of gp41. Yechiel Shai has The Harold S. and Harriet B. Brady Professorial Chair in Cancer Research. This study was supported by the Israel Science Foundation .",
year = "2011",
month = oct,
doi = "10.1016/j.bbamem.2011.06.020",
language = "אנגלית",
volume = "1808",
pages = "2352--2358",
journal = "Biochimica et Biophysica Acta - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier B.V.",
number = "10",
}