TY - JOUR
T1 - Multidrug-resistant Candida haemulonii and C. auris, Tel Aviv, Israel
AU - Ben-Ami, Ronen
AU - Berman, Judith
AU - Novikov, Ana
AU - Bash, Edna
AU - Shachor-Meyouhas, Yael
AU - Zakin, Shiri
AU - Maor, Yasmin
AU - Tarabia, Jalal
AU - Schechner, Vered
AU - Adler, Amos
AU - Finn, Talya
N1 - Publisher Copyright:
© 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2017/2
Y1 - 2017/2
N2 - Candida auris and C. haemulonii are closely related, multidrug-resistant emerging fungal pathogens that are not readily distinguishable with phenotypic assays. We studied C. auris and C. haemulonii clinical isolates from 2 hospitals in central Israel. C. auris was isolated in 5 patients with nosocomial bloodstream infection, and C. haemulonii was found as a colonizer of leg wounds at a peripheral vascular disease clinic. Liberal use of topical miconazole and close contact among patients were implicated in C. haemulonii transmission. C. auris exhibited higher thermotolerance, virulence in a mouse infection model, and ATP-dependent drug efflux activity than C. haemulonii. Comparison of ribosomal DNA sequences found that C. auris strains from Israel were phylogenetically distinct from isolates from East Asia, South Africa and Kuwait, whereas C. haemulonii strains from different countries were closely interrelated. Our findings highlight the pathogenicity of C. auris and underscore the need to limit its spread.
AB - Candida auris and C. haemulonii are closely related, multidrug-resistant emerging fungal pathogens that are not readily distinguishable with phenotypic assays. We studied C. auris and C. haemulonii clinical isolates from 2 hospitals in central Israel. C. auris was isolated in 5 patients with nosocomial bloodstream infection, and C. haemulonii was found as a colonizer of leg wounds at a peripheral vascular disease clinic. Liberal use of topical miconazole and close contact among patients were implicated in C. haemulonii transmission. C. auris exhibited higher thermotolerance, virulence in a mouse infection model, and ATP-dependent drug efflux activity than C. haemulonii. Comparison of ribosomal DNA sequences found that C. auris strains from Israel were phylogenetically distinct from isolates from East Asia, South Africa and Kuwait, whereas C. haemulonii strains from different countries were closely interrelated. Our findings highlight the pathogenicity of C. auris and underscore the need to limit its spread.
UR - http://www.scopus.com/inward/record.url?scp=85009957625&partnerID=8YFLogxK
U2 - 10.3201/eid2302.161486
DO - 10.3201/eid2302.161486
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C2 - 28098529
AN - SCOPUS:85009957625
SN - 1080-6040
VL - 23
SP - 195
EP - 203
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 2
ER -
