Multidrug resistance in Candida albicans: Disruption of the BEN(r) gene

M. Goldway, D. Teff, R. Schmidt, A. B. Oppenheim, Y. Koltin

Research output: Contribution to journalArticlepeer-review

Abstract

The BEN(r) gene of Candida albicans, which confers resistance on susceptible strains of Saccharomyces cerevisiae to six structurally and functionally unrelated drugs, was described recently (R. Ben-Yaacov, S. Knoller, G. Caldwell, J. M. Becker, and Y. Koltin, Antimicrob. Agents Chemother. 38:648-652, 1994). This gene bears similarity to membrane proteins encoding antibiotic resistance in prokaryotes and eukaryotes. The effect of disruption of this gene on viability and drug susceptibility was determined. The results indicate that the gene is not essential but its inactivation leads to susceptibility to three of the four drugs tested. Inactivation of this gene did not increase the susceptibility of the mutant to benomyl, suggesting that C. albicans has other mechanisms of resistance, some of which may be additional efflux pumps that confer resistance to this tubulin- destabilizing agent.

Original languageEnglish
Pages (from-to)422-426
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume39
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

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