Multidimensional NMR spectroscopy in a single scan

Maayan Gal, Lucio Frydman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Multidimensional NMR has become one of the most widespread spectroscopic tools available to study diverse structural and functional aspects of organic and biomolecules. A main feature of multidimensional NMR is the relatively long acquisition times that these experiments demand. For decades, scientists have been working on a variety of alternatives that would enable NMR to overcome this limitation, and deliver its data in shorter acquisition times. Counting among these methodologies is the so-called ultrafast (UF) NMR approach, which in principle allows one to collect arbitrary multidimensional correlations in a single sub-second transient. By contrast to conventional acquisitions, a main feature of UF NMR is a spatiotemporal manipulation of the spins that imprints the chemical shift and/or J-coupling evolutions being sought, into a spatial pattern. Subsequent gradient-based manipulations enable the reading out of this information and its multidimensional correlation into patterns that are identical to those afforded by conventional techniques. The current review focuses on the fundamental principles of this spatiotemporal UF NMR manipulation, and on a few of the methodological extensions that this form of spectroscopy has undergone during the years.

Original languageEnglish
Pages (from-to)971-985
Number of pages15
JournalMagnetic Resonance in Chemistry
Issue number11
StatePublished - 1 Nov 2015
Externally publishedYes


FundersFunder number
Israel Science Foundation1775/12, 795/13


    • Multidimensional NMR
    • Ultrafast NMR
    • single-scan acquisitions
    • spatiotemporal encoding


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