Multicenter GeoSentinel analysis of rickettsial diseases in international travelers, 1996-2008

Mogens Jensenius; Xiaohong Davis; Frank Von Sonnenburg; Eli Schwartz; Jay S. Keystone; Karin Leder; Rogelio Lopéz-Véléz; Eric Caumes; Jakob P. Cramer; Lin Chen; Philippe Parola

doi:10.3201/eid1511.090677

Multicenter GeoSentinel analysis of rickettsial diseases in international travelers, 1996-2008

Mogens Jensenius^*
, Xiaohong Davis
, Frank Von Sonnenburg
, Eli Schwartz
, Jay S. Keystone
, Karin Leder
, Rogelio Lopéz-Véléz
, Eric Caumes
, Jakob P. Cramer
, Lin Chen
, Philippe Parola

^*Corresponding author for this work

University of Oslo
Centers for Disease Control and Prevention
Ludwig Maximilian University of Munich
Sheba Medical Center at Tel Hashomer
Toronto General Hospital
Royal Melbourne Hospital
Hospital Ramon y Cajal
Sorbonne Université
Bernhard Nocht Institute for Tropical Medicine
Harvard University
WHO Collaborative Center for rickettsioses and other arthropod borne bacterial diseases
Hôpital Nord AP-HM

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

We investigated epidemiologic and clinical aspects of rickettsial diseases in 280 international travelers reported to the GeoSentinel Surveillance Network during 1996-2008. Of these 280 travelers, 231 (82.5%) had spotted fever (SFG) rickettsiosis, 16 (5.7%) scrub typhus, 11 (3.9%) Q fever, 10 (3.6%) typhus group (TG) rickettsiosis, 7 (2.5%) bartonellosis, 4 (1.4%) indeterminable SFG/TG rickettsiosis, and 1 (0.4%) human granulocytic anaplasmosis. One hundred ninety-seven (87.6%) SFG rickettsiosis cases were acquired in sub-Saharan Africa and were associated with higher age, male gender, travel to southern Africa, late summer season travel, and travel for tourism. More than 90% of patients with rickettsial disease were treated with doxycycline, 43 (15.4%) were hospitalized, and 4 had a complicated course, including 1 fatal case of scrub typhus encephalitis acquired in Thailand.

Original language	English
Pages (from-to)	1791-1798
Number of pages	8
Journal	Emerging Infectious Diseases
Volume	15
Issue number	11
DOIs	https://doi.org/10.3201/eid1511.090677
State	Published - Nov 2009
Externally published	Yes

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title = "Multicenter GeoSentinel analysis of rickettsial diseases in international travelers, 1996-2008",

abstract = "We investigated epidemiologic and clinical aspects of rickettsial diseases in 280 international travelers reported to the GeoSentinel Surveillance Network during 1996-2008. Of these 280 travelers, 231 (82.5\%) had spotted fever (SFG) rickettsiosis, 16 (5.7\%) scrub typhus, 11 (3.9\%) Q fever, 10 (3.6\%) typhus group (TG) rickettsiosis, 7 (2.5\%) bartonellosis, 4 (1.4\%) indeterminable SFG/TG rickettsiosis, and 1 (0.4\%) human granulocytic anaplasmosis. One hundred ninety-seven (87.6\%) SFG rickettsiosis cases were acquired in sub-Saharan Africa and were associated with higher age, male gender, travel to southern Africa, late summer season travel, and travel for tourism. More than 90\% of patients with rickettsial disease were treated with doxycycline, 43 (15.4\%) were hospitalized, and 4 had a complicated course, including 1 fatal case of scrub typhus encephalitis acquired in Thailand.",

author = "Mogens Jensenius and Xiaohong Davis and \{Von Sonnenburg\}, Frank and Eli Schwartz and Keystone, \{Jay S.\} and Karin Leder and Rogelio Lop{\'e}z-V{\'e}l{\'e}z and Eric Caumes and Cramer, \{Jakob P.\} and Lin Chen and Philippe Parola",

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doi = "10.3201/eid1511.090677",

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AU - Davis, Xiaohong

AU - Von Sonnenburg, Frank

AU - Schwartz, Eli

AU - Keystone, Jay S.

AU - Leder, Karin

AU - Lopéz-Véléz, Rogelio

AU - Caumes, Eric

AU - Cramer, Jakob P.

AU - Chen, Lin

AU - Parola, Philippe

PY - 2009/11

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N2 - We investigated epidemiologic and clinical aspects of rickettsial diseases in 280 international travelers reported to the GeoSentinel Surveillance Network during 1996-2008. Of these 280 travelers, 231 (82.5%) had spotted fever (SFG) rickettsiosis, 16 (5.7%) scrub typhus, 11 (3.9%) Q fever, 10 (3.6%) typhus group (TG) rickettsiosis, 7 (2.5%) bartonellosis, 4 (1.4%) indeterminable SFG/TG rickettsiosis, and 1 (0.4%) human granulocytic anaplasmosis. One hundred ninety-seven (87.6%) SFG rickettsiosis cases were acquired in sub-Saharan Africa and were associated with higher age, male gender, travel to southern Africa, late summer season travel, and travel for tourism. More than 90% of patients with rickettsial disease were treated with doxycycline, 43 (15.4%) were hospitalized, and 4 had a complicated course, including 1 fatal case of scrub typhus encephalitis acquired in Thailand.

AB - We investigated epidemiologic and clinical aspects of rickettsial diseases in 280 international travelers reported to the GeoSentinel Surveillance Network during 1996-2008. Of these 280 travelers, 231 (82.5%) had spotted fever (SFG) rickettsiosis, 16 (5.7%) scrub typhus, 11 (3.9%) Q fever, 10 (3.6%) typhus group (TG) rickettsiosis, 7 (2.5%) bartonellosis, 4 (1.4%) indeterminable SFG/TG rickettsiosis, and 1 (0.4%) human granulocytic anaplasmosis. One hundred ninety-seven (87.6%) SFG rickettsiosis cases were acquired in sub-Saharan Africa and were associated with higher age, male gender, travel to southern Africa, late summer season travel, and travel for tourism. More than 90% of patients with rickettsial disease were treated with doxycycline, 43 (15.4%) were hospitalized, and 4 had a complicated course, including 1 fatal case of scrub typhus encephalitis acquired in Thailand.

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JF - Emerging Infectious Diseases

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Multicenter GeoSentinel analysis of rickettsial diseases in international travelers, 1996-2008

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