Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol

Valentina Kutyifa; Christopher Beck; Mary W. Brown; David Cannom; James Daubert; Mark Estes; Henry Greenberg; Ilan Goldenberg; Stephen Hammes; David Huang; Helmut Klein; Reinoud Knops; Mikhail Kosiborod; Jeanne Poole; Claudio Schuger; Jagmeet P. Singh; Scott Solomon; David Wilber; Wojciech Zareba; Arthur J. Moss

doi:10.1016/j.ahj.2017.04.014

Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol

Valentina Kutyifa^*, Christopher Beck, Mary W. Brown, David Cannom, James Daubert, Mark Estes, Henry Greenberg, Ilan Goldenberg, Stephen Hammes, David Huang, Helmut Klein, Reinoud Knops, Mikhail Kosiborod, Jeanne Poole, Claudio Schuger, Jagmeet P. Singh, Scott Solomon, David Wilber, Wojciech Zareba, Arthur J. Moss

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Patients with diabetes mellitus, prior myocardial infarction, older age, and a relatively preserved left ventricular ejection fraction remain at risk for sudden cardiac death that is potentially amenable by the subcutaneous implantable cardioverter defibrillator with a good risk-benefit profile. The launched MADIT S-ICD study is designed to test the hypothesis that post–myocardial infarction diabetes patients with relatively preserved ejection fraction of 36%-50% will have a survival benefit from a subcutaneous implantable cardioverter defibrillator.

Original language	English
Pages (from-to)	158-166
Number of pages	9
Journal	American Heart Journal
Volume	189
DOIs	https://doi.org/10.1016/j.ahj.2017.04.014
State	Published - 1 Jul 2017
Externally published	Yes

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Kutyifa, V., Beck, C., Brown, M. W., Cannom, D., Daubert, J., Estes, M., Greenberg, H., Goldenberg, I., Hammes, S., Huang, D., Klein, H., Knops, R., Kosiborod, M., Poole, J., Schuger, C., Singh, J. P., Solomon, S., Wilber, D., Zareba, W., & Moss, A. J. (2017). Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol. American Heart Journal, 189, 158-166. https://doi.org/10.1016/j.ahj.2017.04.014

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title = "Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol",

abstract = "Patients with diabetes mellitus, prior myocardial infarction, older age, and a relatively preserved left ventricular ejection fraction remain at risk for sudden cardiac death that is potentially amenable by the subcutaneous implantable cardioverter defibrillator with a good risk-benefit profile. The launched MADIT S-ICD study is designed to test the hypothesis that post–myocardial infarction diabetes patients with relatively preserved ejection fraction of 36%-50% will have a survival benefit from a subcutaneous implantable cardioverter defibrillator.",

author = "Valentina Kutyifa and Christopher Beck and Brown, {Mary W.} and David Cannom and James Daubert and Mark Estes and Henry Greenberg and Ilan Goldenberg and Stephen Hammes and David Huang and Helmut Klein and Reinoud Knops and Mikhail Kosiborod and Jeanne Poole and Claudio Schuger and Singh, {Jagmeet P.} and Scott Solomon and David Wilber and Wojciech Zareba and Moss, {Arthur J.}",

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doi = "10.1016/j.ahj.2017.04.014",

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Kutyifa, V, Beck, C, Brown, MW, Cannom, D, Daubert, J, Estes, M, Greenberg, H, Goldenberg, I, Hammes, S, Huang, D, Klein, H, Knops, R, Kosiborod, M, Poole, J, Schuger, C, Singh, JP, Solomon, S, Wilber, D, Zareba, W & Moss, AJ 2017, 'Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol', American Heart Journal, vol. 189, pp. 158-166. https://doi.org/10.1016/j.ahj.2017.04.014

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AU - Beck, Christopher

AU - Brown, Mary W.

AU - Cannom, David

AU - Daubert, James

AU - Estes, Mark

AU - Greenberg, Henry

AU - Goldenberg, Ilan

AU - Hammes, Stephen

AU - Huang, David

AU - Klein, Helmut

AU - Knops, Reinoud

AU - Kosiborod, Mikhail

AU - Poole, Jeanne

AU - Schuger, Claudio

AU - Singh, Jagmeet P.

AU - Solomon, Scott

AU - Wilber, David

AU - Zareba, Wojciech

AU - Moss, Arthur J.

PY - 2017/7/1

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ER -

Multicenter Automatic Defibrillator Implantation Trial–Subcutaneous Implantable Cardioverter Defibrillator (MADIT S-ICD): Design and clinical protocol

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