Mucosal healing is associated with the reduced disabling disease in Crohn’s disease

Shanshan Huang, Li Li, Shomron Ben-Horin, Ren Mao, Sinan Lin, Yun Qiu, Rui Feng, Yao He, Baili Chen, Zhirong Zeng, Minhu Chen, Shenghong Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


OBJECTIVES: Mucosal healing (MH) is the goal of the “treat to target” strategy in Crohn’s disease (CD), which seeks to prevent disability. However, evidence is limited regarding whether achieving MH can reduce disability in CD. We aimed to estimate the probability of disabling disease and to investigate the association between MH and disabling disease in CD. METHODS: This was a retrospective case-control study of 319 consecutive CD patients. The primary outcome was disabling disease occurrence (defined as surgery, hospitalizations, steroid dependency, or disease complications). The secondary endpoint was disabling disease recurrence. The Kaplan-Meier method and Cox proportional hazards model were used to calculate cumulative rates and for multivariate analysis, respectively. RESULTS: Of 319 CD patients (median follow-up time: 42.4 months, interquartile range: 24.7–60.0 months), 105 (32.9%) progressed to disabling disease and 20 (6.3%) had the recurrence of disabling disease. The cumulative rates of disabling disease were 11.3%, 30.2%, and 44.9% at 1, 3, and 5 years, respectively, after diagnosis. MH was associated with a significantly lower frequency of surgery, new penetrating event, and new stenosis (P50.004, P50.001, P5 0.002, respectively). Univariate and multivariate analyses revealed that MH was an independent protective factor of disabling disease occurrence (hazard ratio: 0.166, 95% confidence interval: 0.084–0.329). CONCLUSIONS: Disabling disease was common in Chinese CD patients and increased during follow-up. Moreover, MH was significantly associated with a reduced occurrence of disabling disease in CD.

Original languageEnglish
Article numbere-00015
JournalClinical and Translational Gastroenterology
Issue number3
StatePublished - 1 Mar 2019


FundersFunder number
Guangdong Science and Technology2017A030306021, 2016A020214006
National Natural Science Foundation of ChinaNSFC
Science and Technology Innovation Young Talents of Guangdong Special Support Plan2016TQ03R296
National Natural Science Foundation of China81630018, 81870374, 81670498
Pearl River S and T Nova Program of Guangzhou201610010126


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