MR-guided focus ultrasound (MRgFUS) for symptomatic uterine fibroids: Predictors of treatment success

Ronit MacHtinger, Yael Inbar, Shlomo Cohen-Eylon, Dahlia Admon, Aviva Alagem-Mizrachi, Jaron Rabinovici*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


STUDY QUESTIONWhat are the factors associated with long-term success in patients with symptomatic uterine fibroids treated by magnetic resonance-guided focus ultrasound (MRgFUS) and can they be employed to create a clinically useful index that predicts long-term efficacy?SUMMARY ANSWERHypo-intense fibroids on T2-weighted magnetic resonance imaging (MRI) and older age were associated with higher success rates and can be used to predict success rates on the basis of their presence or absence as pre-treatment parameters. WHAT IS KNOWN ALREADYThe signal intensity of baseline T2-weighted MRI images and non-perfused volume at the end of the treatment can be correlated with MRgFUS outcome. STUDY DESIGN, SIZE AND DURATIONThis was a retrospective analysis of 81 patients who were treated by MRgFUS for symptomatic uterine fibroids, in an academic affiliated center between 2003 and 2008. PARTICIPANTS/MATERIALS, SETTING AND METHODSThere was a post-treatment phone interview >6 months following MRgFUS for symptomatic uterine fibroids. MAIN RESULTS AND THE ROLE OF CHANCEThe eighty-one patients completed a successful MRgFUS treatment during this period, of whom 74 were included in the final analysis (1 was post-menopausal at treatment and 5 were lost for follow-up). The mean time for the phone interview was 33. 0 ± 15. 1 months (range: 6-53 months) after the MRgFUS treatment. Fifty-five patients (69) did not need any additional alternative treatment following MRgFUS. Nineteen patients (24) underwent other surgical interventions. Hypo-intense fibroids were associated with a higher chance of success than hyper-intense fibroids [odds ratio 2. 96 (1. 01-8. 71); P=0. 04] for surgery in hyper-intense fibroids). Women with long-term treatment success were significantly older at the time of treatment [46. 3 ± 3. 8 (range: 37-53) years versus 43. 6 ± 4. 4 (range: 36-51) years, respectively; P=0. 02]. LIMITATIONS AND REASONS FOR CAUTIONRetrospective non-comparative studies are suboptimal and might overemphasize favorable outcomes. WIDER IMPLICATIONS OF THE FINDINGSThis paper can contribute to selection of suitable candidates for the MRgFUS treatment for patients with uterine fibroids' and can serve as a guide for gynecologists for a better patient selection. STUDY FUNDING/COMPETING INTEREST(S)None. TRIAL REGISTRATION NUMBERN/A.

Original languageEnglish
Pages (from-to)3425-3431
Number of pages7
JournalHuman Reproduction
Issue number12
StatePublished - Dec 2012


  • MRgFUS
  • long-term outcome
  • uterine fibroids


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