Moving ahead on harnessing synthetic lethality to fight cancer

Livnat Jerby-Arnon; Eytan Ruppin

doi:10.4161/23723556.2014.977150

Moving ahead on harnessing synthetic lethality to fight cancer

Livnat Jerby-Arnon, Eytan Ruppin

School of Computer Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer.

Original language	English
Article number	e977150
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	2
DOIs	https://doi.org/10.4161/23723556.2014.977150
State	Published - 3 Apr 2015

Keywords

cancer genomics
genetic interactions
precision medicine
synthetic lethality

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/23723556.2014.977150

Cite this

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Moving ahead on harnessing synthetic lethality to fight cancer

Abstract

Keywords

UN SDGs

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