Abstract
We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer.
Original language | English |
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Article number | e977150 |
Journal | Molecular and Cellular Oncology |
Volume | 2 |
Issue number | 2 |
DOIs | |
State | Published - 3 Apr 2015 |
Keywords
- cancer genomics
- genetic interactions
- precision medicine
- synthetic lethality