Moving ahead on harnessing synthetic lethality to fight cancer

Livnat Jerby-Arnon, Eytan Ruppin

Research output: Contribution to journalArticlepeer-review

Abstract

We have recently developed a data-mining pipeline that comprehensively identifies cancer unique susceptibilities, following the concept of Synthetic Lethality (SL). The approach enables, for the first time, to identify and harness genome-scale SL-networks to accurately predict gene essentiality, drug response, and clinical prognosis in cancer.

Original languageEnglish
Article numbere977150
JournalMolecular and Cellular Oncology
Volume2
Issue number2
DOIs
StatePublished - 3 Apr 2015

Keywords

  • cancer genomics
  • genetic interactions
  • precision medicine
  • synthetic lethality

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