TY - JOUR
T1 - Mouse models for human deafness
T2 - Current tools for new fashions
AU - Ahituv, Nadav
AU - Avraham, Karen B.
N1 - Funding Information:
K.B.A.'s work on mouse models for human deafness is supported by grants from the European Commission (QLG2-CT-1999–00988), the Israel Ministry of Health and the Israel Academy of Sciences. We thank Corne Kros, David Gurwitz, Martine Cohen-Salmon, Ari Elson and Yehoash Raphael for valuable comments; Tama Hasson for myosin VIIa antibodies; and Ronna Hertzano and Varda Wexler for figures. This review is dedicated to the memory of George D. Snell, a pioneer in mouse genetics, whose ‘namesake’ – Snell's waltzer – introduced us to the world of mouse models for deafness.
PY - 2002/9
Y1 - 2002/9
N2 - Mouse models are one of the major tools used for discovery and characterization of genes for non-syndromic deafness in humans. The similarities between the mouse and human genomes, and between the physiology and morphology of their auditory systems, are striking. This article describes the latest mouse models, including spontaneous, 'knockout' and ENU (N-ethyl-N-nitrosourea)-induced mutants, and the recent discovery of modifier genes that are involved in mouse deafness; this discovery is leading the search for genetic modifiers for human disorders.
AB - Mouse models are one of the major tools used for discovery and characterization of genes for non-syndromic deafness in humans. The similarities between the mouse and human genomes, and between the physiology and morphology of their auditory systems, are striking. This article describes the latest mouse models, including spontaneous, 'knockout' and ENU (N-ethyl-N-nitrosourea)-induced mutants, and the recent discovery of modifier genes that are involved in mouse deafness; this discovery is leading the search for genetic modifiers for human disorders.
UR - http://www.scopus.com/inward/record.url?scp=0036725601&partnerID=8YFLogxK
U2 - 10.1016/S1471-4914(02)02388-2
DO - 10.1016/S1471-4914(02)02388-2
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AN - SCOPUS:0036725601
VL - 8
SP - 447
EP - 451
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 9
ER -