Mouse models for human deafness: Current tools for new fashions

Nadav Ahituv, Karen B. Avraham*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Mouse models are one of the major tools used for discovery and characterization of genes for non-syndromic deafness in humans. The similarities between the mouse and human genomes, and between the physiology and morphology of their auditory systems, are striking. This article describes the latest mouse models, including spontaneous, 'knockout' and ENU (N-ethyl-N-nitrosourea)-induced mutants, and the recent discovery of modifier genes that are involved in mouse deafness; this discovery is leading the search for genetic modifiers for human disorders.

Original languageEnglish
Pages (from-to)447-451
Number of pages5
JournalTrends in Molecular Medicine
Issue number9
StatePublished - Sep 2002


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