Mouse models for human deafness: Current tools for new fashions

Nadav Ahituv, Karen B. Avraham

Research output: Contribution to journalReview articlepeer-review

Abstract

Mouse models are one of the major tools used for discovery and characterization of genes for non-syndromic deafness in humans. The similarities between the mouse and human genomes, and between the physiology and morphology of their auditory systems, are striking. This article describes the latest mouse models, including spontaneous, 'knockout' and ENU (N-ethyl-N-nitrosourea)-induced mutants, and the recent discovery of modifier genes that are involved in mouse deafness; this discovery is leading the search for genetic modifiers for human disorders.

Original languageEnglish
Pages (from-to)447-451
Number of pages5
JournalTrends in Molecular Medicine
Volume8
Issue number9
DOIs
StatePublished - Sep 2002

Fingerprint

Dive into the research topics of 'Mouse models for human deafness: Current tools for new fashions'. Together they form a unique fingerprint.

Cite this