TY - JOUR
T1 - Mouse models for deafness
T2 - Lessons for the human inner ear and hearing loss
AU - Avraham, Karen B.
PY - 2003/8
Y1 - 2003/8
N2 - In the field of hearing research, recent advances using the mouse as a model for human hearing loss have brought exciting insights into the molecular pathways that lead to normal hearing, and into the mechanisms that are disrupted once a mutation occurs in one of the critical genes. Inaccessible for most procedures other than high-resolution computed tomography (CT) scanning or invasive surgery, most studies on the ear in humans can only be performed postmortem. A major goal in hearing research is to gain a full understanding of how a sound is heard at the molecular level, so that diagnostic and eventually therapeutic interventions can be developed that can treat the diseased inner ear before permanent damage has occurred, such as hair cell loss. The mouse, with its advantages of short gestation time, ease of selective matings, and similarity of the genome and inner ear to humans, is truly a remarkable resource for attaining this goal and investigating the intrigues of the human ear.
AB - In the field of hearing research, recent advances using the mouse as a model for human hearing loss have brought exciting insights into the molecular pathways that lead to normal hearing, and into the mechanisms that are disrupted once a mutation occurs in one of the critical genes. Inaccessible for most procedures other than high-resolution computed tomography (CT) scanning or invasive surgery, most studies on the ear in humans can only be performed postmortem. A major goal in hearing research is to gain a full understanding of how a sound is heard at the molecular level, so that diagnostic and eventually therapeutic interventions can be developed that can treat the diseased inner ear before permanent damage has occurred, such as hair cell loss. The mouse, with its advantages of short gestation time, ease of selective matings, and similarity of the genome and inner ear to humans, is truly a remarkable resource for attaining this goal and investigating the intrigues of the human ear.
UR - http://www.scopus.com/inward/record.url?scp=0043281577&partnerID=8YFLogxK
U2 - 10.1097/01.AUD.0000079840.96472.DB
DO - 10.1097/01.AUD.0000079840.96472.DB
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AN - SCOPUS:0043281577
SN - 0196-0202
VL - 24
SP - 332
EP - 341
JO - Ear and Hearing
JF - Ear and Hearing
IS - 4
ER -