TY - JOUR
T1 - Motion magnification analysis of microscopy videos of biological cells
AU - Shabi, Oren
AU - Natan, Sari
AU - Kolel, Avraham
AU - Mukherjee, Abhishek
AU - Tchaicheeyan, Oren
AU - Wolfenson, Haguy
AU - Kiryati, Nahum
AU - Lesman, Ayelet
N1 - Publisher Copyright:
© 2020 Shabi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - It is well recognized that isolated cardiac muscle cells beat in a periodic manner. Recently, evidence indicates that other, non-muscle cells, also perform periodic motions that are either imperceptible under conventional lab microscope lens or practically not easily amenable for analysis of oscillation amplitude, frequency, phase of movement and its direction. Here, we create a real-time video analysis tool to visually magnify and explore sub-micron rhythmic movements performed by biological cells and the induced movements in their surroundings. Using this tool, we suggest that fibroblast cells perform small fluctuating movements with a dominant frequency that is dependent on their surrounding substrate and its stiffness.
AB - It is well recognized that isolated cardiac muscle cells beat in a periodic manner. Recently, evidence indicates that other, non-muscle cells, also perform periodic motions that are either imperceptible under conventional lab microscope lens or practically not easily amenable for analysis of oscillation amplitude, frequency, phase of movement and its direction. Here, we create a real-time video analysis tool to visually magnify and explore sub-micron rhythmic movements performed by biological cells and the induced movements in their surroundings. Using this tool, we suggest that fibroblast cells perform small fluctuating movements with a dominant frequency that is dependent on their surrounding substrate and its stiffness.
UR - http://www.scopus.com/inward/record.url?scp=85095738918&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0240127
DO - 10.1371/journal.pone.0240127
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C2 - 33151976
AN - SCOPUS:85095738918
SN - 1932-6203
VL - 15
JO - PLoS ONE
JF - PLoS ONE
IS - 11
M1 - e0240127
ER -