Mother–Child Interaction as a Window to a Unique Social Phenotype in 22q11.2 Deletion Syndrome and in Williams Syndrome

Omri Weisman, Ruth Feldman, Merav Burg-Malki, Miri Keren, Ronny Geva, Gil Diesendruck, Doron Gothelf

Research output: Contribution to journalArticlepeer-review

Abstract

Mother-child interactions in 22q11.2 Deletion syndrome (22q11.2DS) and Williams syndrome (WS) were coded for maternal sensitivity/intrusiveness, child’s expression of affect, levels of engagement, and dyadic reciprocity. WS children were found to express more positive emotions towards their mothers compared to 22q11.2DS children and those with developmental delay in a conflict interaction. During the same interaction, dyads of 22q11.2DS children were characterized by higher levels of maternal intrusiveness, lower levels of child’s engagement and reduced reciprocity compared to dyads of typically developing children. Finally, 22q11.2DS children with the COMT Met allele showed less adaptive behaviors than children with the Val allele. Dyadic behaviors partially coincided with the distinct social phenotypes in these syndromes and are potential behavioral markers of psychopathological trajectory.

Original languageEnglish
Pages (from-to)2567-2577
Number of pages11
JournalJournal of Autism and Developmental Disorders
Volume45
Issue number8
DOIs
StatePublished - 27 Aug 2015

Keywords

  • 22q11.2DS
  • Behavior
  • COMT gene
  • Mother–child interaction
  • Williams syndrome

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