TY - JOUR
T1 - Mortality and morbidity in preterm small-for-gestational-age infants
T2 - A population-based study
AU - Grisaru-Granovsky, Sorina
AU - Reichman, Brian
AU - Lerner-Geva, Liat
AU - Boyko, Valentina
AU - Hammerman, Cathy
AU - Samueloff, Arnon
AU - Schimmel, Michael S.
N1 - Funding Information:
The Israel National Very-Low-Birth-Weight Infant Database is supported, in part, by the Israel Center for Disease Control and the Ministry of Health.
PY - 2012/2
Y1 - 2012/2
N2 - Objective: We sought to evaluate the impact of severity of growth restriction on mortality and major neonatal morbidity among very-low-birthweight small-for-gestational-age infants. Study Design: This was a population-based observational study using data collected by the Israel National Very-Low-Birth-Weight Infant Database 1995 through 2007 including infants 24-31 weeks' gestation, with birthweight (BW) ≤50th percentile without major malformations. Four BW percentile groups were considered: <3rd, 3rd-<10th, 10th-<25th, and a reference group 25th-50th percentile. Univariate and multivariable logistic regression analyses were performed. Results: Infants of BW 3rd-<10th percentile were at increased risk for grades 3-4 retinopathy of prematurity (odds ratio [OR], 2.07; 95% confidence interval [CI], 1.542.78), bronchopulmonary dysplasia (OR, 2.52; 95% CI, 2.033.12), necrotizing enterocolitis (OR, 1.32; 95% CI, 1.041.68), and mortality (OR, 2.37; 95% CI, 1.942.90). The risk was further increased among infants of BW <3rd percentile. Conclusion: Growth restriction severity may serve as a clinical marker of degree of risk for neonatal mortality and various morbidities.
AB - Objective: We sought to evaluate the impact of severity of growth restriction on mortality and major neonatal morbidity among very-low-birthweight small-for-gestational-age infants. Study Design: This was a population-based observational study using data collected by the Israel National Very-Low-Birth-Weight Infant Database 1995 through 2007 including infants 24-31 weeks' gestation, with birthweight (BW) ≤50th percentile without major malformations. Four BW percentile groups were considered: <3rd, 3rd-<10th, 10th-<25th, and a reference group 25th-50th percentile. Univariate and multivariable logistic regression analyses were performed. Results: Infants of BW 3rd-<10th percentile were at increased risk for grades 3-4 retinopathy of prematurity (odds ratio [OR], 2.07; 95% confidence interval [CI], 1.542.78), bronchopulmonary dysplasia (OR, 2.52; 95% CI, 2.033.12), necrotizing enterocolitis (OR, 1.32; 95% CI, 1.041.68), and mortality (OR, 2.37; 95% CI, 1.942.90). The risk was further increased among infants of BW <3rd percentile. Conclusion: Growth restriction severity may serve as a clinical marker of degree of risk for neonatal mortality and various morbidities.
KW - growth percentile
KW - morbidity
KW - mortality
KW - small for gestational age
KW - very low birthweight
UR - http://www.scopus.com/inward/record.url?scp=84856380827&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2011.08.025
DO - 10.1016/j.ajog.2011.08.025
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AN - SCOPUS:84856380827
SN - 0002-9378
VL - 206
SP - 150.e1-150.e7
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 2
ER -
