Abstract
Background: Mortalin was shown to contribute to removal of the complement membranolytic C5b-9 complex from the target cell surface. Results: Modulations of mortalin expression and activity affect deposition of C5b-9 and cell death. Conclusion: Mortalin, through its ATPase domain, regulates the C5b-9 deposition and confers resistance to complement-dependent cytotoxicity. Significance: Mortalin is a potential therapeutic target in autoimmune diseases and in cancer immunotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 15014-15022 |
| Number of pages | 9 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 21 |
| DOIs | |
| State | Published - 2014 |
