Morphological evaluation of lateral ventricles of fetuses with ventriculomegaly by three-dimensional ultrasonography and magnetic resonance imaging: Correlation with etiology

Karina Krajden Haratz, Luciano Marcondes Mac Hado Nardozza, Patrícia Soares De Oliveira, Liliam Cristine Rolo, Hérbene José Figuinha Milani, Enoch Quinderé De Sá Barreto, Edward Araujo Júnior, Sérgio Aron Ajzen, Antonio Fernandes Moron

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose To evaluate morphology of lateral ventricles of ventriculomegaly/hydrocephaly fetuses using 3D-sonography by virtual organ computer-aided analysis (VOCAL) technique and magnetic resonance imaging (MRI) and verify morphologic patterns related to etiology. Methods Seventeen fetuses presenting with ventricular enlargement (atria > 10 mm) were evaluated. 3D datasets were acquired from a coronal reference plane and post-processed by the rotational imaging using VOCAL 30°. MRI study was analyzed in the three plans in all sequences. Morphologic aspects such as global shape, anterior, posterior and inferior horn characteristics, wall irregularities and deformities were analyzed and related to etiology factor. Results Twenty-nine percent of the cases were secondary to Arnold-Chiari syndrome and presented with global dilation of the three-horns. Cases related to aqueduct stenosis presented with ependymal rupture and wall irregularities in advanced cases. Corpus callosum agenesis cases presented with small ventricular volumes, thin shape, normal or slightly enlarged anterior and inferior horns with dilation restricted to posterior horn. Cases related to trisomy 18 and cytomegalovirus presented irregular ventricular walls associated with anomalous ventricular shapes, suggesting parenchymal destruction. Conclusion Ventricular morphology evaluation gives important information on etiology of ventricular enlargement, supporting prognosis prediction and decision making process of the aVected fetuses and their families.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalArchives of Gynecology and Obstetrics
Volume284
Issue number2
DOIs
StatePublished - Aug 2011
Externally publishedYes

Keywords

  • Etiology
  • Fetuses
  • Magnetic resonance imaging
  • Morphology
  • Three-dimensional ultrasonography
  • Ventriculomegaly

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