TY - JOUR
T1 - Morphogenesis and cell cycle progression in Candida albicans
AU - Berman, Judith
N1 - Funding Information:
I thank Ken Finley for producing ( Figures 2 and 3 ) and Pete Sudbery for providing photomicrographs for ( Figure 2 ). I am grateful to Kelly Bouchonville, Ken Finley, Cheryl Gale, Neil Gow and Pete Sudbery for helpful discussions and for comments on the manuscript. I apologize to the many authors whose work could not be cited because of space limitations. This work was supported by an award from the National Institutes of Health (R01 AI/DE14666).
PY - 2006/12
Y1 - 2006/12
N2 - Candida albicans, an opportunistic human pathogen, displays three modes of growth: yeast, pseudohyphae and true hyphae, all of which differ both in morphology and in aspects of cell cycle progression. In particular, in hyphal cells, polarized growth becomes uncoupled from other cell cycle events. Yeast or pseudohyphae that undergo a cell cycle delay also exhibit polarized growth, independent of cell cycle progression. The Spitzenkörper, an organelle composed of vesicles associated with hyphal tips, directs continuous hyphal elongation in filamentous fungal species and also in C. albicans hyphae. A polarisome mediates cell cycle dependent growth in yeast and pseudohyphae. Regulation of morphogenesis and cell cycle progression is dependent upon specific cyclins, all of which affect morphogenesis and some of which function specifically in yeast or hyphal cells. Future work will probably focus on the cell cycle checkpoints involved in connecting morphogenesis to cell cycle progression.
AB - Candida albicans, an opportunistic human pathogen, displays three modes of growth: yeast, pseudohyphae and true hyphae, all of which differ both in morphology and in aspects of cell cycle progression. In particular, in hyphal cells, polarized growth becomes uncoupled from other cell cycle events. Yeast or pseudohyphae that undergo a cell cycle delay also exhibit polarized growth, independent of cell cycle progression. The Spitzenkörper, an organelle composed of vesicles associated with hyphal tips, directs continuous hyphal elongation in filamentous fungal species and also in C. albicans hyphae. A polarisome mediates cell cycle dependent growth in yeast and pseudohyphae. Regulation of morphogenesis and cell cycle progression is dependent upon specific cyclins, all of which affect morphogenesis and some of which function specifically in yeast or hyphal cells. Future work will probably focus on the cell cycle checkpoints involved in connecting morphogenesis to cell cycle progression.
UR - http://www.scopus.com/inward/record.url?scp=33751331633&partnerID=8YFLogxK
U2 - 10.1016/j.mib.2006.10.007
DO - 10.1016/j.mib.2006.10.007
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AN - SCOPUS:33751331633
SN - 1369-5274
VL - 9
SP - 595
EP - 601
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 6
ER -