Morphine versus nalbuphine for postoperative pain relief using the patient-controlled analgesia method

D. Niv, I. Wolman, E. Alon*, A. Weinbroum, V. Rudick, G. Varrassi, E. Geller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The aim of the study was to examine the analgesic efficacy, side effects, and applicability of the two opioids nalbuphine and morphine, administered intravenously with the patient-controlled analgesia method (PCA). Forty-eight patients were studied after surgical and gynecological procedures in a randomized, double blind order. The patients received postoperatively either morphine or nalbuphine and were allowed to self-administer the drugs according to their needs. Analgesia, side effects and patient satisfaction as well as blood pressure, heart rate, respiratory rate, and pulse oxymetric O2-saturation were measured regularly during the postoperative period. The results show that intravenous nalbuphine in the doses used and combined with the patient-controlled analgesia method in this study was as effective as morphine in relieving postoperative pain. Both drugs proved to produce sufficient analgesia with minimal side-effects. Especially important was the fact that no respiratory depression was observed.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalEUR.J.PAIN
Volume16
Issue number1-2
StatePublished - 1995
Externally publishedYes

Keywords

  • Morphine
  • Nalbuphine
  • Patient controlled analgesia
  • Postoperative pain

Fingerprint

Dive into the research topics of 'Morphine versus nalbuphine for postoperative pain relief using the patient-controlled analgesia method'. Together they form a unique fingerprint.

Cite this