Abstract
The aim of the study was to examine the analgesic efficacy, side effects, and applicability of the two opioids nalbuphine and morphine, administered intravenously with the patient-controlled analgesia method (PCA). Forty-eight patients were studied after surgical and gynecological procedures in a randomized, double blind order. The patients received postoperatively either morphine or nalbuphine and were allowed to self-administer the drugs according to their needs. Analgesia, side effects and patient satisfaction as well as blood pressure, heart rate, respiratory rate, and pulse oxymetric O2-saturation were measured regularly during the postoperative period. The results show that intravenous nalbuphine in the doses used and combined with the patient-controlled analgesia method in this study was as effective as morphine in relieving postoperative pain. Both drugs proved to produce sufficient analgesia with minimal side-effects. Especially important was the fact that no respiratory depression was observed.
Original language | English |
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Pages (from-to) | 52-55 |
Number of pages | 4 |
Journal | EUR.J.PAIN |
Volume | 16 |
Issue number | 1-2 |
State | Published - 1995 |
Externally published | Yes |
Keywords
- Morphine
- Nalbuphine
- Patient controlled analgesia
- Postoperative pain