Mood disorders in elderly population: Neurostimulative treatment possibilities

Oded Rosenberg, Netta Shoenfeld, Moshe Kotler, Pinhas N. Dannon*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Treatment of mood disorders is one of the most challenging territories in elderly. Effectiveness of different treatment strategies could be related to age, sex and physical conditions. The side effect profile in this population also affects pharmacological interventions. Our review includes the neurostimulative treatment strategies in elderly. However, possible treatment strategies such as electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS) and deep brain stimulation (DBS) were less studied in elderly. ECT was found to be an effective treatment procedure in mood disorders. Few double-blind sham controlled studies were conducted and demonstrated effectiveness of TMS. DBS has lack of double-blind studies. ECT seems to be the golden standard for the treatment resistant elderly patients, yet side effect profile of ECT in elderly will be discussed. Double -blind sham controlled studies with larger samples are necessary to confirm preliminary results with transcranial direct current stimulation (tDCS), magnetic seizure therapy (MST) and VNS, DBS.

Original languageEnglish
Pages (from-to)149-155
Number of pages7
JournalRecent Patents on CNS Drug Discovery
Issue number2
StatePublished - 2009
Externally publishedYes


  • Affective disorders
  • DBS
  • Depression
  • ECT
  • Elderly
  • Mood disorders
  • TMS
  • VNS


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