Monoclonal lymphocyte proliferation and bcl‐2 rearrangement in essential mixed cryoglobulinaemia

M. ELLIS, M. RATHAUS, A. AMIEL, Y. MANOR, A. KLEIN, M. LISHNER

Research output: Contribution to journalComment/debate

Abstract

Abstract. A patient with essential mixed cryoglobulinaemia (EMC) type II and hepatitis C virus (HCV) infection, in whom immunophenotypic and genotypic studies demonstrated a clonal proliferation of B lymphocytes, is described. Fluorescent in situ hybridization with probes to Ig heavy chain gene and to the oncogene bcl‐2 demonstrated a translocation of bcl‐2 to the immunoglobulin heavy chain locus on chromosome 14. A sharp rise in the level of the monoclonal IgM was associated with a second genetic aberration [t(8:22) (q24:q11)]. No other clinical evidence of disease progression could be demonstrated. Low grade lymphoproliferative disorder with typical cyto‐genetic abnormalities developed on the background of EMC and HCV. Clinical progression was associated with a second genetic abnormality involving the myc oncogene. It is possible that HCV chronic infection may indirectly influence oncogenes associated with lymphoma.

Original languageEnglish
Pages (from-to)833-837
Number of pages5
JournalEuropean Journal of Clinical Investigation
Volume25
Issue number11
DOIs
StatePublished - Nov 1995

Keywords

  • bc1‐2 Rearrangement
  • cryoglobulinaemia
  • hepatitis C virus
  • myc oncogene

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