Abstract
Abstract. A patient with essential mixed cryoglobulinaemia (EMC) type II and hepatitis C virus (HCV) infection, in whom immunophenotypic and genotypic studies demonstrated a clonal proliferation of B lymphocytes, is described. Fluorescent in situ hybridization with probes to Ig heavy chain gene and to the oncogene bcl‐2 demonstrated a translocation of bcl‐2 to the immunoglobulin heavy chain locus on chromosome 14. A sharp rise in the level of the monoclonal IgM was associated with a second genetic aberration [t(8:22) (q24:q11)]. No other clinical evidence of disease progression could be demonstrated. Low grade lymphoproliferative disorder with typical cyto‐genetic abnormalities developed on the background of EMC and HCV. Clinical progression was associated with a second genetic abnormality involving the myc oncogene. It is possible that HCV chronic infection may indirectly influence oncogenes associated with lymphoma.
Original language | English |
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Pages (from-to) | 833-837 |
Number of pages | 5 |
Journal | European Journal of Clinical Investigation |
Volume | 25 |
Issue number | 11 |
DOIs |
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State | Published - Nov 1995 |
Keywords
- bc1‐2 Rearrangement
- cryoglobulinaemia
- hepatitis C virus
- myc oncogene