Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs

Gabriella Goldberg, Daria Mochly-Rosen, Sara Fuchs, Yoram Lass

Research output: Contribution to journalArticlepeer-review

Abstract

Monoclonal antibodies directed against the cholinergic binding site of the acetylcholine receptor were found to alter the ion channel properties in cultured chick "myoballs." Time and dose dependent reduction in acetylcholine sensitivity was observed. Noise analysis experiments indicated a decrease in the mean single channel conductance and an increase in the mean single channel open time.

Original languageEnglish
Pages (from-to)123-128
Number of pages6
JournalJournal of Membrane Biology
Volume76
Issue number2
DOIs
StatePublished - Sep 1983

Keywords

  • ACh noise
  • acetylcholine receptor
  • ionic channel
  • monoclonal antibody

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