Abstract
Monoclonal antibodies directed against the cholinergic binding site of the acetylcholine receptor were found to alter the ion channel properties in cultured chick "myoballs." Time and dose dependent reduction in acetylcholine sensitivity was observed. Noise analysis experiments indicated a decrease in the mean single channel conductance and an increase in the mean single channel open time.
Original language | English |
---|---|
Pages (from-to) | 123-128 |
Number of pages | 6 |
Journal | Journal of Membrane Biology |
Volume | 76 |
Issue number | 2 |
DOIs | |
State | Published - Sep 1983 |
Keywords
- ACh noise
- acetylcholine receptor
- ionic channel
- monoclonal antibody