Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs

Gabriella Goldberg; Daria Mochly-Rosen; Sara Fuchs; Yoram Lass

doi:10.1007/BF02000612

Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs

Gabriella Goldberg^*, Daria Mochly-Rosen, Sara Fuchs, Yoram Lass

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Monoclonal antibodies directed against the cholinergic binding site of the acetylcholine receptor were found to alter the ion channel properties in cultured chick "myoballs." Time and dose dependent reduction in acetylcholine sensitivity was observed. Noise analysis experiments indicated a decrease in the mean single channel conductance and an increase in the mean single channel open time.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	Journal of Membrane Biology
Volume	76
Issue number	2
DOIs	https://doi.org/10.1007/BF02000612
State	Published - Sep 1983

Keywords

ACh noise
acetylcholine receptor
ionic channel
monoclonal antibody

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10.1007/BF02000612

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title = "Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs",

abstract = "Monoclonal antibodies directed against the cholinergic binding site of the acetylcholine receptor were found to alter the ion channel properties in cultured chick {"}myoballs.{"} Time and dose dependent reduction in acetylcholine sensitivity was observed. Noise analysis experiments indicated a decrease in the mean single channel conductance and an increase in the mean single channel open time.",

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author = "Gabriella Goldberg and Daria Mochly-Rosen and Sara Fuchs and Yoram Lass",

year = "1983",

month = sep,

doi = "10.1007/BF02000612",

language = "אנגלית",

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AU - Goldberg, Gabriella

AU - Mochly-Rosen, Daria

AU - Fuchs, Sara

AU - Lass, Yoram

PY - 1983/9

Y1 - 1983/9

N2 - Monoclonal antibodies directed against the cholinergic binding site of the acetylcholine receptor were found to alter the ion channel properties in cultured chick "myoballs." Time and dose dependent reduction in acetylcholine sensitivity was observed. Noise analysis experiments indicated a decrease in the mean single channel conductance and an increase in the mean single channel open time.

AB - Monoclonal antibodies directed against the cholinergic binding site of the acetylcholine receptor were found to alter the ion channel properties in cultured chick "myoballs." Time and dose dependent reduction in acetylcholine sensitivity was observed. Noise analysis experiments indicated a decrease in the mean single channel conductance and an increase in the mean single channel open time.

KW - ACh noise

KW - acetylcholine receptor

KW - ionic channel

KW - monoclonal antibody

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JO - Journal of Membrane Biology

JF - Journal of Membrane Biology

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ER -

Monoclonal antibodies modify acetylcholine-induced ionic channel properties in cultured chick myoballs

Abstract

Keywords

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