TY - JOUR
T1 - Monochorionic diamniotic in vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome
AU - Ben-Ami, Ido
AU - Molina, Francisca Sonia
AU - Battino, Shlomo
AU - Daniel-Spiegel, Etty
AU - Melcer, Yaakov
AU - Flöck, Anne
AU - Geipel, Annegret
AU - Odeh, Marwan
AU - Miron, Pierre
AU - Maymon, Ron
N1 - Publisher Copyright:
© 2016 American Society for Reproductive Medicine.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Objective To compare the incidence of twin-to-twin transfusion syndrome (TTTS) in spontaneous versus IVF-conceived twin pregnancies. Design Retrospective multicenter study. Setting University-affiliated tertiary medical centers. Patient(s) Women admitted for 11-14 week's scan between January 1997 and July 2013 who were diagnosed with monochorionic (MC) diamniotic twin pregnancies. Intervention(s) None. Main Outcome Measure(s) Mode of conception, TTTS. Result(s) The study cohort included 327 pregnant women with live MC diamniotic twins. Of them, 284 (86.9%) and 43 (13.1%) were spontaneous and IVF conceived, respectively. The mean maternal age was significantly higher in IVF compared with in spontaneously conceived pregnancies (33.8 ± 5.5 vs. 31.6 ± 5.4, respectively). Thirty-seven twins (11.3%) had TTTS, of whom 36/284 (12.7%) versus 1/43 (2.3%) were spontaneously and IVF conceived, respectively. The mean week of delivery was significantly lower in MC twins diagnosed with TTTS compared with those without TTTS (32.7 ± 3.3 vs. 35.5 ± 2.5, respectively). Furthermore, there was a significantly higher birthweight discordancy in twins diagnosed with TTTS compared with those without (20.6% vs. 11%, respectively). Conclusion(s) The significantly lower proportion of TTTS found in IVF-conceived twins may suggest a different embryological process that lies at the core of IVF conception of monozygotic twinning.
AB - Objective To compare the incidence of twin-to-twin transfusion syndrome (TTTS) in spontaneous versus IVF-conceived twin pregnancies. Design Retrospective multicenter study. Setting University-affiliated tertiary medical centers. Patient(s) Women admitted for 11-14 week's scan between January 1997 and July 2013 who were diagnosed with monochorionic (MC) diamniotic twin pregnancies. Intervention(s) None. Main Outcome Measure(s) Mode of conception, TTTS. Result(s) The study cohort included 327 pregnant women with live MC diamniotic twins. Of them, 284 (86.9%) and 43 (13.1%) were spontaneous and IVF conceived, respectively. The mean maternal age was significantly higher in IVF compared with in spontaneously conceived pregnancies (33.8 ± 5.5 vs. 31.6 ± 5.4, respectively). Thirty-seven twins (11.3%) had TTTS, of whom 36/284 (12.7%) versus 1/43 (2.3%) were spontaneously and IVF conceived, respectively. The mean week of delivery was significantly lower in MC twins diagnosed with TTTS compared with those without TTTS (32.7 ± 3.3 vs. 35.5 ± 2.5, respectively). Furthermore, there was a significantly higher birthweight discordancy in twins diagnosed with TTTS compared with those without (20.6% vs. 11%, respectively). Conclusion(s) The significantly lower proportion of TTTS found in IVF-conceived twins may suggest a different embryological process that lies at the core of IVF conception of monozygotic twinning.
KW - IVF
KW - TTTS
KW - incidence
KW - monozygosity
KW - twins
UR - http://www.scopus.com/inward/record.url?scp=84959563201&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2015.11.036
DO - 10.1016/j.fertnstert.2015.11.036
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 26690011
AN - SCOPUS:84959563201
SN - 0015-0282
VL - 105
SP - 729
EP - 733
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 3
ER -