Monitoring the transport and phosphorylation of 2-deoxy-D-glucose in tumor cells in vivo and in vitro by 13C nuclear magnetic resonance spectroscopy

Gil Navon, Robbe C. Lyon, Ofer Kaplan, Jack S. Cohen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We describe the use of 2-deoxy-D-[6-13C]glucose to follow simultaneously, by 13C NMR, both transport and phosporylation to its 6-phosphate form, in MCF-7 breast cancer cells in vitro and in vivo in subcutaneous tumors in nude mice.

Original languageEnglish
Pages (from-to)86-90
Number of pages5
JournalFEBS Letters
Volume247
Issue number1
DOIs
StatePublished - 10 Apr 1989
Externally publishedYes

Keywords

  • (Cancer cell, Tumor)
  • Deoxy-D-glucose, 2-
  • Glycolysis
  • Labeling, C
  • NMR, C-
  • Phosphorylation
  • Transport

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