Monitoring the efficiency of photodynamic therapy in tissue

A. Orenstein; S. Kimel; B. J. Tromberg; J. S. Nelson; M. W. Berns

doi:10.1117/12.17614

Monitoring the efficiency of photodynamic therapy in tissue

A. Orenstein^*, S. Kimel, B. J. Tromberg, J. S. Nelson, M. W. Berns

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Transcutaneous oxygen electrodes are used to non-invasively measure tissue oxygen tension during photodynamic therapy (PDT). Measurements are performed on VX-2 skin carcinomas in rabbit ears. The degree of tumor oxygen tension reduction is proportional to the applied light dose. In the absence of irradiation, oxygen tension returns to pre-irradiation levels until a 'damage threshold' has been reached. For 50mW/cm² irradiations of Photofrin II (at 630 nm) and tetraphenylporphine tetrasulfonate (at 657 nm), the cumulative dose required to irreversibly deplete tumor transcutaneous oxygen was approximately 300 kJ/m² and 600 kJ/m², respectively.

Original language	English
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Publisher	Publ by Int Soc for Optical Engineering
Pages	88-92
Number of pages	5
ISBN (Print)	0819402435, 9780819402431
DOIs	https://doi.org/10.1117/12.17614
State	Published - 1990
Externally published	Yes
Event	Proceedings of Laser-Tissue Interaction - Los Angeles, CA, USA Duration: 15 Jan 1990 → 17 Jan 1990

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	1202
ISSN (Print)	0277-786X

Conference

Conference	Proceedings of Laser-Tissue Interaction
City	Los Angeles, CA, USA
Period	15/01/90 → 17/01/90

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Orenstein, A., Kimel, S., Tromberg, B. J., Nelson, J. S., & Berns, M. W. (1990). Monitoring the efficiency of photodynamic therapy in tissue. In Proceedings of SPIE - The International Society for Optical Engineering (pp. 88-92). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1202). Publ by Int Soc for Optical Engineering. https://doi.org/10.1117/12.17614

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title = "Monitoring the efficiency of photodynamic therapy in tissue",

abstract = "Transcutaneous oxygen electrodes are used to non-invasively measure tissue oxygen tension during photodynamic therapy (PDT). Measurements are performed on VX-2 skin carcinomas in rabbit ears. The degree of tumor oxygen tension reduction is proportional to the applied light dose. In the absence of irradiation, oxygen tension returns to pre-irradiation levels until a 'damage threshold' has been reached. For 50mW/cm2 irradiations of Photofrin II (at 630 nm) and tetraphenylporphine tetrasulfonate (at 657 nm), the cumulative dose required to irreversibly deplete tumor transcutaneous oxygen was approximately 300 kJ/m2 and 600 kJ/m2, respectively.",

author = "A. Orenstein and S. Kimel and Tromberg, {B. J.} and Nelson, {J. S.} and Berns, {M. W.}",

year = "1990",

doi = "10.1117/12.17614",

language = "אנגלית",

isbn = "0819402435",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "Publ by Int Soc for Optical Engineering",

pages = "88--92",

booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

note = "Proceedings of Laser-Tissue Interaction ; Conference date: 15-01-1990 Through 17-01-1990",

}

Orenstein, A, Kimel, S, Tromberg, BJ, Nelson, JS & Berns, MW 1990, Monitoring the efficiency of photodynamic therapy in tissue. in Proceedings of SPIE - The International Society for Optical Engineering. Proceedings of SPIE - The International Society for Optical Engineering, vol. 1202, Publ by Int Soc for Optical Engineering, pp. 88-92, Proceedings of Laser-Tissue Interaction, Los Angeles, CA, USA, 15/01/90. https://doi.org/10.1117/12.17614

Monitoring the efficiency of photodynamic therapy in tissue. / Orenstein, A.; Kimel, S.; Tromberg, B. J. et al.
Proceedings of SPIE - The International Society for Optical Engineering. Publ by Int Soc for Optical Engineering, 1990. p. 88-92 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1202).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Transcutaneous oxygen electrodes are used to non-invasively measure tissue oxygen tension during photodynamic therapy (PDT). Measurements are performed on VX-2 skin carcinomas in rabbit ears. The degree of tumor oxygen tension reduction is proportional to the applied light dose. In the absence of irradiation, oxygen tension returns to pre-irradiation levels until a 'damage threshold' has been reached. For 50mW/cm2 irradiations of Photofrin II (at 630 nm) and tetraphenylporphine tetrasulfonate (at 657 nm), the cumulative dose required to irreversibly deplete tumor transcutaneous oxygen was approximately 300 kJ/m2 and 600 kJ/m2, respectively.

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Monitoring the efficiency of photodynamic therapy in tissue

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