Monitoring the efficiency of photodynamic therapy in tissue

A. Orenstein*, S. Kimel, B. J. Tromberg, J. S. Nelson, M. W. Berns

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Transcutaneous oxygen electrodes are used to non-invasively measure tissue oxygen tension during photodynamic therapy (PDT). Measurements are performed on VX-2 skin carcinomas in rabbit ears. The degree of tumor oxygen tension reduction is proportional to the applied light dose. In the absence of irradiation, oxygen tension returns to pre-irradiation levels until a 'damage threshold' has been reached. For 50mW/cm2 irradiations of Photofrin II (at 630 nm) and tetraphenylporphine tetrasulfonate (at 657 nm), the cumulative dose required to irreversibly deplete tumor transcutaneous oxygen was approximately 300 kJ/m2 and 600 kJ/m2, respectively.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Int Soc for Optical Engineering
Number of pages5
ISBN (Print)0819402435, 9780819402431
StatePublished - 1990
Externally publishedYes
EventProceedings of Laser-Tissue Interaction - Los Angeles, CA, USA
Duration: 15 Jan 199017 Jan 1990

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


ConferenceProceedings of Laser-Tissue Interaction
CityLos Angeles, CA, USA


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