Monitoring of the effect of intervertebral disc nucleus pulposus ablation by MRI

Galit Saar, Yoram Zilberman, Hadassah Shinar, Keren Keinan-Adamsky, Gadi Pelled, Dan Gazit, Gil Navon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In order to investigate intervertebral disc (IVD) degeneration and repair, a quantitative non-invasive tool is needed. Various MRI methods including qCPMG, which yields dipolar echo relaxation time (TDE), magnetization transfer contrast (MTC), and 1H and 2H double quantum filtered (DQF) MRI were used in the present work to monitor changes in rat IVD after ablation of the nucleus pulposus (NP), serving as a model of severe IVD degeneration. In the intact IVD, a clear distinction between the annulus fibrosus (AF) and the NP is obtained on T2 and TDE weighted images as well as on MTC maps, reflecting the high concentration of ordered collagen fibers in the AF. After ablation of the NP, the distinction between the compartments is lost. T2 and TDE relaxation times are short throughout the disc and MTC is high. 1H and 2H DQF signal, which in intact discs is obtained only for the AF, is now observable throughout the tissue. These results indicate that after ablation, there is an ingression of collagen fibers from the AF into the area that was previously occupied by the NP, as was confirmed by histology.

Original languageEnglish
Pages (from-to)554-562
Number of pages9
JournalNMR in Biomedicine
Issue number6
StatePublished - Jul 2010


  • Annulus fibrosus
  • Double quantum filtered MRI
  • Intervertebral disc
  • MRI
  • MTR maps
  • Nucleus pulposus


Dive into the research topics of 'Monitoring of the effect of intervertebral disc nucleus pulposus ablation by MRI'. Together they form a unique fingerprint.

Cite this