Molecular signaling in bone regeneration

H. Bahar, Dafna Benayahu, A. Yaffe, I. Binderman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Regeneration is the ability of cells to restore lost or damaged tissues and organs in adults by pathways that mimic developmental processes. Although many of the molecular mechanisms that control cellular differentiation and growth during embryogenesis recur during fracture healing, these processes take place in a postnatal environment that is unique and distinct from those that exist during embryogenesis. Bone tissue has a remarkable capacity of regeneration without scarring. This article highlights central biological and molecular processes that are crucial in embryonic bone development. Several animal bone regeneration models are described. The patterns of gene expression during the regeneration process in the different models are reviewed. Exploring the similarities and the differences in the molecular processes in different models will contribute to the understanding of their potential in the processes of bone regeneration and tissue engineering.

Original languageEnglish
Pages (from-to)87-101
Number of pages15
JournalCritical Reviews in Eukaryotic Gene Expression
Issue number2
StatePublished - 2007


  • Bone regeneration
  • Gene expression
  • Models in vivo of bone regeneration


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