Molecular Risk Factors for Schizophrenia

Shira Modai, Noam Shomron

Research output: Contribution to journalReview articlepeer-review

Abstract

Schizophrenia (SZ) is a complex and strongly heritable mental disorder, which is also associated with developmental-environmental triggers. As opposed to most diagnosable diseases (yet similar to other mental disorders), SZ diagnosis is commonly based on psychiatric evaluations. Recently, large-scale genetic and epigenetic approaches have been applied to SZ research with the goal of potentially improving diagnosis. Increased computational analyses and applied statistical algorithms may shed some light on the complex genetic and epigenetic pathways contributing to SZ pathogenesis. This review discusses the latest advances in molecular risk factors and diagnostics for SZ. Approaches such as these may lead to a more accurate definition of SZ and assist in creating extended and reliable clinical diagnoses with the potential for personalized treatment.

Original languageEnglish
Pages (from-to)242-253
Number of pages12
JournalTrends in Molecular Medicine
Volume22
Issue number3
DOIs
StatePublished - 1 Mar 2016

Keywords

  • Biomarker
  • Diagnosis
  • Epigenetic
  • Genetic
  • High throughput
  • Risk factor
  • Schizophrenia

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