@article{f7adca80b2244ff39ed43d1ecd94f853,
title = "Molecular probe for enzymatic activity with dual output",
abstract = "A novel molecular probe for enzymatic activity with a dual output detection-mode has been developed. The probe effectively detected the presence of the bacterial protease penicillin-G-amidase; a single cleavage by the enzyme initiated the fragmentation of a self-immolative dendritic platform to release two reporter units. The signals of the free reporters were detected by two different spectroscopic techniques, fluorescence and UV-vis. This is the first reported molecular probe with two different chromogenic reporter units activated by a specific stimulus.",
keywords = "Assay, Dendrimer, Enzyme, Molecular probe, Self-immolative",
author = "Eyal Danieli and Doron Shabat",
note = "Funding Information: D.S. thanks the Israel Science Foundation and the Israel Ministry of Science {\textquoteleft}Tashtiot{\textquoteright} program for financial support. ",
year = "2007",
month = dec,
day = "1",
doi = "10.1016/j.bmc.2007.08.046",
language = "אנגלית",
volume = "15",
pages = "7318--7324",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ltd.",
number = "23",
}