TY - JOUR
T1 - Molecular mechanisms underlying alcohol-drinking behaviours
AU - Ron, Dorit
AU - Barak, Segev
N1 - Funding Information:
This Review is supported by the US National Institute on Alcohol Abuse and Alcoholism (NIAAA) of the National Institutes of Health (NIH-NIAAA RO1 AA016848, NIAAA R37 AA016848, NIH-NIAAAP50 AA017072, R01AA014366 and U01AA023489) to D.R. and by the Israel Science Foundation (ISF 96813 and 191613), the Brain and Behavior Research Foundation (NARSAD 19114), the German Israel Foundation (GIF I-2348-105.4/2014) and the National Institute of Psychobiology in Israel (NIPI 110-14-15) to S.B.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - The main characteristic of alcohol use disorder is the consumption of large quantities of alcohol despite the negative consequences. The transition from the moderate use of alcohol to excessive, uncontrolled alcohol consumption results from neuroadaptations that cause aberrant motivational learning and memory processes. Here, we examine studies that have combined molecular and behavioural approaches in rodents to elucidate the molecular mechanisms that keep the social intake of alcohol in check, which we term 'stop pathways', and the neuroadaptations that underlie the transition from moderate to uncontrolled, excessive alcohol intake, which we term 'go pathways'. We also discuss post-transcriptional, genetic and epigenetic alterations that underlie both types of pathways.
AB - The main characteristic of alcohol use disorder is the consumption of large quantities of alcohol despite the negative consequences. The transition from the moderate use of alcohol to excessive, uncontrolled alcohol consumption results from neuroadaptations that cause aberrant motivational learning and memory processes. Here, we examine studies that have combined molecular and behavioural approaches in rodents to elucidate the molecular mechanisms that keep the social intake of alcohol in check, which we term 'stop pathways', and the neuroadaptations that underlie the transition from moderate to uncontrolled, excessive alcohol intake, which we term 'go pathways'. We also discuss post-transcriptional, genetic and epigenetic alterations that underlie both types of pathways.
UR - http://www.scopus.com/inward/record.url?scp=84979270635&partnerID=8YFLogxK
U2 - 10.1038/nrn.2016.85
DO - 10.1038/nrn.2016.85
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AN - SCOPUS:84979270635
SN - 1471-003X
VL - 17
SP - 576
EP - 591
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 9
ER -
