Molecular mechanisms of preeclampsia

Tammy Hod, Ana Sofia Cerdeira, S. Ananth Karumanchi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Preeclampsia is a pregnancy-specific disease characterized by new onset hypertension and proteinuria after 20 wk of gestation. It is a leading cause of maternal and fetal morbidity and mortality worldwide. Exciting discoveries in the last decade have contributed to a better understanding of the molecular basis of this disease. Epidemiological, experimental, and therapeutic studies from several laboratories have provided compelling evidence that an antiangiogenic state owing to alterations in circulating angiogenic factors leads to preeclampsia. In this review, we highlight the role of key circulating antiangiogenic factors as pathogenic biomarkers and in the development of novel therapies for preeclampsia.

Original languageEnglish
Article numbera023473
JournalCold Spring Harbor perspectives in medicine
Volume5
Issue number10
DOIs
StatePublished - Oct 2015
Externally publishedYes

Funding

FundersFunder number
National Heart, Lung, and Blood InstituteHL079594
National Institute of Diabetes and Digestive and Kidney DiseasesDK 065997

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