Molecular mechanisms of nickel carcinogenesis

H. Cangul, L. Broday, K. Salnikow, J. Sutherland, W. Peng, Q. Zhang, V. Poltaratsky, H. Yee, M. A. Zoroddu, M. Costa

Research output: Contribution to journalReview articlepeer-review

Abstract

Humans are exposed to carcinogenic nickel (Ni) compounds both occupationally and environmentally. In this paper, molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel sulfide particles in cells, their dissolution and their effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing, DNA hypermethylation and inhibition of histone acetylation, will be discussed.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalToxicology Letters
Volume127
Issue number1-3
DOIs
StatePublished - 28 Feb 2002
Externally publishedYes

Keywords

  • Chromosome damage
  • Gene silencing
  • Heterochromatin
  • Nickel

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