Molecular mechanisms of nickel carcinogenesis

H. Cangul, L. Broday, K. Salnikow, J. Sutherland, W. Peng, Q. Zhang, V. Poltaratsky, H. Yee, M. A. Zoroddu, M. Costa

Research output: Contribution to journalReview articlepeer-review


Humans are exposed to carcinogenic nickel (Ni) compounds both occupationally and environmentally. In this paper, molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel sulfide particles in cells, their dissolution and their effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing, DNA hypermethylation and inhibition of histone acetylation, will be discussed.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalToxicology Letters
Issue number1-3
StatePublished - 28 Feb 2002
Externally publishedYes


  • Chromosome damage
  • Gene silencing
  • Heterochromatin
  • Nickel


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