TY - JOUR
T1 - Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments
AU - Kessler-Icekson, G.
AU - Barhum, Y.
AU - Schlesinger, H.
AU - Shohat, J.
AU - Sharma, H.
AU - Schaper, W.
AU - Vatner, S.
AU - Reneman, R.
AU - Janicki, J.
AU - Ter Keurs, H. E.D.J.
AU - Solaro, J.
PY - 1995
Y1 - 1995
N2 - Antihypertensive treatments were given to young and adult SHRs, to prevent and reverse hypertension, respectively. Cardiac hypertrophy and the steady state level of the 'fetal' genes, ANP, α-skeletal actin (α-skA), and β myosin heavy chain (β-MHC) mRNAs were assessed. Our findings show that the reduction of blood pressure does not consistently result in a similar regression of the 'fetal gene program'.
AB - Antihypertensive treatments were given to young and adult SHRs, to prevent and reverse hypertension, respectively. Cardiac hypertrophy and the steady state level of the 'fetal' genes, ANP, α-skeletal actin (α-skA), and β myosin heavy chain (β-MHC) mRNAs were assessed. Our findings show that the reduction of blood pressure does not consistently result in a similar regression of the 'fetal gene program'.
UR - http://www.scopus.com/inward/record.url?scp=0029128146&partnerID=8YFLogxK
U2 - 10.1007/978-1-4615-1893-8_20
DO - 10.1007/978-1-4615-1893-8_20
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C2 - 8540396
AN - SCOPUS:0029128146
SN - 0065-2598
VL - 382
SP - 195
EP - 203
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -