Molecular insights into the reversible formation of tau protein fibrils

Yin Luo; Paul Dinkel; Xiang Yu; Martin Margittai; Jie Zheng; Ruth Nussinov; Guanghong Wei; Buyong Ma

doi:10.1039/c3cc00241a

Molecular insights into the reversible formation of tau protein fibrils

Yin Luo, Paul Dinkel, Xiang Yu, Martin Margittai, Jie Zheng, Ruth Nussinov, Guanghong Wei^*, Buyong Ma

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We computationally and experimentally showed that tau protein fibrils can be formed at high temperature. When cooled, the fibrils dissociate back to monomers. Heparin promotes tau fibril formation and prevents its reversion. Our results revealed the physicochemical mechanism of reversible formation of tau fibrils.

Original language	English
Pages (from-to)	3582-3584
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	34
DOIs	https://doi.org/10.1039/c3cc00241a
State	Published - 2 Apr 2013

Funding

Funders	Funder number
National Cancer Institute	ZIABC010440

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title = "Molecular insights into the reversible formation of tau protein fibrils",

abstract = "We computationally and experimentally showed that tau protein fibrils can be formed at high temperature. When cooled, the fibrils dissociate back to monomers. Heparin promotes tau fibril formation and prevents its reversion. Our results revealed the physicochemical mechanism of reversible formation of tau fibrils.",

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AU - Nussinov, Ruth

AU - Wei, Guanghong

AU - Ma, Buyong

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Molecular insights into the reversible formation of tau protein fibrils

Abstract

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