Molecular engineering of somatostatin analogue with minimal dipeptide motif induces the formation of functional nanoparticles

Talia Shekhter Zahavi, Mor Oron-Herman, Genady Kostenich, Eyal Rub, Yoseph Salitra, Ludmila Buzhansky, Arie Orenstein, Ehud Gazit, Lihi Adler-Abramovich

Research output: Contribution to journalArticlepeer-review

Abstract

Functionalized nanoparticles decorated with functional biological entities serve as preferred vehicles for numerous theranostic applications. Here we offer an alternative strategy in which the targeting moieties also act as building blocks for the formation of functional nanoassemblies. Diphenylalanine, a small, highly potent self-assembling module, was incorporated with a somatostatin analogue, a modified hormone which preferentially binds to cancer cells. The co-assembly of the engineered hormone together with the structurally diverse diphenylalanine derivative allowed the formation of bioactive homogenous spherical nanostructures. Significant internalization capacity of the loaded co-assembled nanospheres into cancer cells in vitro, as well as selective in vivo accumulation in tumors, were demonstrated. These findings present a new method for the molecular engineering of bioactive peptide molecules by minor modifications with a remarkably potent association motif.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalChemNanoMat
Volume3
Issue number1
DOIs
StatePublished - Jan 2017

Keywords

  • Co-assembly
  • Nanocarriers
  • Selfassembly
  • Supramolecular chemistry
  • Targeted drug delivery

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