@article{a5732e913226407fbe4db1774292e831,
title = "Molecular dynamics simulations of palmitate entry into the hydrophobic pocket of the fatty acid binding protein",
abstract = "The entry of substrate into the active site is the first event in any enzymatic reaction. However, due to the short time interval between the encounter and the formation of the stable complex, the detailed steps are experimentally unobserved. In the present study, we report a molecular dynamics simulation of the encounter between palmitate molecule and the Toad Liver fatty acid binding protein, ending with the formation of a stable complex resemblance in structure of other proteins of this family. The forces operating on the system leading to the formation of the tight complex are discussed.",
keywords = "Fatty acid binding proteins, Molecular dynamics, Molecular modeling, Palmitic acid",
author = "Yossi Tsfadia and Ran Friedman and Jonathan Kadmon and Anna Selzer and Esther Nachliel and Menachem Gutman",
note = "Funding Information: This study was supported by the United States–Israel Binational Science Foundation (2002129). R.F. greatly acknowledges the Colton Foundation for supporting him through the Colton Fellowship. ",
year = "2007",
month = mar,
day = "20",
doi = "10.1016/j.febslet.2007.02.033",
language = "אנגלית",
volume = "581",
pages = "1243--1247",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "6",
}