TY - JOUR
T1 - Molecular cytogenetic parameters in Ewing sarcoma
AU - Amiel, A.
AU - Ohali, A.
AU - Fejgin, M.
AU - Sardos-Albertini, F.
AU - Bouaron, N.
AU - Cohen, I. J.
AU - Yaniv, I.
AU - Zaizov, R.
AU - Avigad, S.
PY - 2003/1/15
Y1 - 2003/1/15
N2 - To evaluate possible genomic instability and possible random aneuploidy, we applied comparative genomic hybridization and fluorescence in situ techniques, and evaluated telomerase activity in 16 cases of Ewing sarcoma (EWS) and compared the results to 7 controls. Common secondary aberrations (gains of chromosomes 8 and 12) were found in the study group. There was a direct correlation between the detection of random aneuploidy and development of tumor relapse (P = 0.0047). Other detectable abnormal parameters (secondary) and high telomerase activity were also more common among the cases with relapse but did not reach a statistical significance (probably because of the small sample size). In EWS, the detection of random aneuploidy seems to be a sensitive parameter in the prediction of tumor relapse.
AB - To evaluate possible genomic instability and possible random aneuploidy, we applied comparative genomic hybridization and fluorescence in situ techniques, and evaluated telomerase activity in 16 cases of Ewing sarcoma (EWS) and compared the results to 7 controls. Common secondary aberrations (gains of chromosomes 8 and 12) were found in the study group. There was a direct correlation between the detection of random aneuploidy and development of tumor relapse (P = 0.0047). Other detectable abnormal parameters (secondary) and high telomerase activity were also more common among the cases with relapse but did not reach a statistical significance (probably because of the small sample size). In EWS, the detection of random aneuploidy seems to be a sensitive parameter in the prediction of tumor relapse.
UR - http://www.scopus.com/inward/record.url?scp=0037438774&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(02)00659-3
DO - 10.1016/S0165-4608(02)00659-3
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AN - SCOPUS:0037438774
SN - 0165-4608
VL - 140
SP - 107
EP - 112
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -