Molecular cytogenetic parameters in Ewing sarcoma

A. Amiel, A. Ohali, M. Fejgin, F. Sardos-Albertini, N. Bouaron, I. J. Cohen, I. Yaniv, R. Zaizov, S. Avigad

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate possible genomic instability and possible random aneuploidy, we applied comparative genomic hybridization and fluorescence in situ techniques, and evaluated telomerase activity in 16 cases of Ewing sarcoma (EWS) and compared the results to 7 controls. Common secondary aberrations (gains of chromosomes 8 and 12) were found in the study group. There was a direct correlation between the detection of random aneuploidy and development of tumor relapse (P = 0.0047). Other detectable abnormal parameters (secondary) and high telomerase activity were also more common among the cases with relapse but did not reach a statistical significance (probably because of the small sample size). In EWS, the detection of random aneuploidy seems to be a sensitive parameter in the prediction of tumor relapse.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume140
Issue number2
DOIs
StatePublished - 15 Jan 2003

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