TY - JOUR
T1 - Molecular biology of nickel carcinogenesis
AU - Costa, M.
AU - Sutherland, J. E.
AU - Peng, W.
AU - Salnikow, K.
AU - Broday, L.
AU - Kluz, T.
PY - 2001
Y1 - 2001
N2 - A review of the molecular mechanisms of nickel carcinogenesis has been compiled. This work is based upon approximately 20 years of research conducted in my laboratory. Molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel, both soluble and insoluble particles in cells, its dissolution and its effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing in cells by DNA hypermethylation in mammalian cells and by inhibiting histone acetylation in yeast cells are also discussed.
AB - A review of the molecular mechanisms of nickel carcinogenesis has been compiled. This work is based upon approximately 20 years of research conducted in my laboratory. Molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel, both soluble and insoluble particles in cells, its dissolution and its effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing in cells by DNA hypermethylation in mammalian cells and by inhibiting histone acetylation in yeast cells are also discussed.
KW - Gene silencing
KW - Molecular mechanisms
KW - Nickel carcinogenesis
UR - http://www.scopus.com/inward/record.url?scp=0034802637&partnerID=8YFLogxK
U2 - 10.1023/A:1017978500031
DO - 10.1023/A:1017978500031
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C2 - 11678603
AN - SCOPUS:0034802637
SN - 0300-8177
VL - 222
SP - 205
EP - 211
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
IS - 1-2
ER -