Molecular and therapeutic aspects of hyperbaric oxygen therapy in neurological conditions

Inbar Fischer, Boaz Barak*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


In hyperbaric oxygen therapy (HBOT), the subject is placed in a chamber containing 100% oxygen gas at a pressure of more than one atmosphere absolute. This treatment is used to hasten tissue recovery and improve its physiological aspects, by providing an increased supply of oxygen to the damaged tissue. In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. We discuss the efficacy of HBOT in treating neurological conditions and neurodevelopmental disorders in both humans and animal models. We summarize by discussing the challenges in this field, and explore future directions that will allow the scientific community to better understand the molecular aspects and applications of HBOT for a wide variety of neurological conditions.

Original languageEnglish
Article number1247
Pages (from-to)1-17
Number of pages17
Issue number9
StatePublished - Sep 2020


  • Angiogenesis
  • Autistic spectrum disorder
  • Cerebral palsy
  • Hyperbaric oxygen therapy
  • Hypoxia
  • Mitochondria
  • Neurodevelopmental disorders
  • Neurological conditions
  • Reactive oxygen stress
  • Traumatic brain injury
  • White matter


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