Molecular analysis of childhood acute lymphoblastic leukemia in Israel

Orit Blau, Smadar Avigad, Amos Frisch, Yael Kilim, Batia Stark, Yona Kodman, Drorit Luria, Ian J. Cohen, Rina Zaizov

Research output: Contribution to journalArticlepeer-review

Abstract

Ninety-two Israeli children with acute lymphoblastic leukemia (ALL) (67 B-lineage and 25 T-lineage) were analyzed for the immunological antigen receptor gene configuration. Thirty-nine of the patients (27 B-lineage and 12 T-lineage) relapsed. The incidence of the identified rearrangements within the immunoglobulin heavy chain (IgH) and T-cell receptor (TCR)β, γ and δ genes, at diagnosis, was in accordance with previous studies from other countries. Furthermore, the clinical relevance of bi/oligoclonal status, at diagnosis, and clonal selection was determined in this long-term follow-up study (median 112 months). A similar relapse rate was observed among the B-lineage patients with bi/oligoclonal and monoclonal patterns indicated by IgH gene rearrangement. Based on our results, we suggest that bi/oligoclonality has no prognostic significance (P = 0.8533). Clonal variations between diagnosis and subsequent relapses were detected in 60% (12/20) of the patients: 64% (7/11) B-lineage and 55% (5/9) T-lineage. Clonal selection significantly correlated with shorter duration of remission and earlier recurrence (P = 0.0025).

Original languageEnglish
Pages (from-to)495-500
Number of pages6
JournalLeukemia Research
Volume22
Issue number6
DOIs
StatePublished - Jun 1998

Keywords

  • Acute lymphoblastic leukemia
  • Childhood
  • Immunoglobulin
  • Rearrangement
  • T-cell receptor

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