Modulatory Effects of Thyroxine Treatment on Central and Peripheral Benzodiazepine Receptors in the Rat

M. Gavish*, A. Weizman, F. Okun, M. B.H. Youdim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract The effects of 10 days of D‐thyroxine (T4) treatment on central benzodiazepine (BZ) receptors in the brain and on peripheral‐type BZ binding sites in the heart, kidney, and testis of rats were studied. The experimental hyperthyroidism resulted in an increase in the density of cortical central BZ receptors, without any alteration of the affinity of the receptors to [3H]flunitrazepam. The increase in cortical central BZ receptors was also accompanied by the up‐regulation of peripheral BZ binding sites in the heart, kidney, and testis. The affinity of the peripheral BZ binding sites for the Iigand [3H]PK 11195 was not affected by T4 treatment in any of these three organs. The increase in the density of brain cortical central BZ receptors was less prominent than the increase in the peripheral BZ binding sites. The modulatory effect of T4 treatment on central and peripheral BZ receptors might be attributed to the direct interaction of the thyroid hormone at these sites or might reflect a physiological compensatory adaptation mechanism to thyrotoxicosis associated with hypermetabolism, anxiety, and stress.

Original languageEnglish
Pages (from-to)1106-1110
Number of pages5
JournalJournal of Neurochemistry
Volume47
Issue number4
DOIs
StatePublished - Oct 1986
Externally publishedYes

Keywords

  • Central benzodiazepine receptors
  • Peripheral benzodiazepine binding sites
  • Thyroxine
  • [H]Flunitrazepam
  • [H]PK 11195.

Fingerprint

Dive into the research topics of 'Modulatory Effects of Thyroxine Treatment on Central and Peripheral Benzodiazepine Receptors in the Rat'. Together they form a unique fingerprint.

Cite this