Modulation of the skeletal muscle sodium channel α-subunit by the β1 -subunit

Martin Wallner*, Lukas Weigl, Pratap Meera, Ilana Lotan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Co-expression of cloned sodium channel β1 -subunit with the rat skeletal muscle-subunit (αμI) accelerated the macroscopic current decay, enhanced the current amplitude, shifted the steady state inactivation curve to more negative potentials and decreased the time required for complete recovery from inactivation. Sodium channels expressed from skeletal muscle mRNA showed a similar behaviour to that observed from αμI β1, indicating that β1 restores 'physiological' behaviour. Northern blot analysis revealed that the Na+ channel β1-subunit is present in high abundance (about 0.1%) in rat heart, brain and skeletal muscle, and the hybridization with untranslated region of the 'brain' β1 cDNA to skeletal muscle and heart mRNA indicated that the diffferent Na + channel α-subunits in brain, skeletal muscle and heart may share a common β1 -subunit.

Original languageEnglish
Pages (from-to)535-539
Number of pages5
JournalFEBS Letters
Volume336
Issue number3
DOIs
StatePublished - 28 Dec 1993

Keywords

  • Expression
  • Sodium channel
  • Translational control
  • Xenopus oocyte
  • α-Subunit
  • β-Subunit

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